Multi-Scale Flexible Fitting of Proteins to Cryo-EM Density Maps at Medium Resolution

Structure determination using cryo-electron microscopy (cryo-EM) medium-resolution density maps is often facilitated by flexible fitting. Avoiding overfitting, adjusting force constants driving the structure to the density map, and emulating complex conformational transitions are major concerns in t...

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Detalles Bibliográficos
Autores principales: Kulik, Marta, Mori, Takaharu, Sugita, Yuji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8025875/
https://www.ncbi.nlm.nih.gov/pubmed/33842541
http://dx.doi.org/10.3389/fmolb.2021.631854

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8025875/
https://www.ncbi.nlm.nih.gov/pubmed/33842541
http://dx.doi.org/10.3389/fmolb.2021.631854

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