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Multi-Scale Flexible Fitting of Proteins to Cryo-EM Density Maps at Medium Resolution
Structure determination using cryo-electron microscopy (cryo-EM) medium-resolution density maps is often facilitated by flexible fitting. Avoiding overfitting, adjusting force constants driving the structure to the density map, and emulating complex conformational transitions are major concerns in t...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8025875/ https://www.ncbi.nlm.nih.gov/pubmed/33842541 http://dx.doi.org/10.3389/fmolb.2021.631854 |