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The structure of Prp2 bound to RNA and ADP-BeF(3) (−) reveals structural features important for RNA unwinding by DEAH-box ATPases

Noncoding intron sequences present in precursor mRNAs need to be removed prior to translation, and they are excised via the spliceosome, a multimegadalton molecular machine composed of numerous protein and RNA components. The DEAH-box ATPase Prp2 plays a crucial role during pre-mRNA splicing as it e...

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Detalles Bibliográficos
Autores principales:	Hamann, Florian, Zimmerningkat, Lars C., Becker, Robert A., Garbers, Tim B., Neumann, Piotr, Hub, Jochen S., Ficner, Ralf
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	International Union of Crystallography 2021
Materias:	Research Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8025883/ https://www.ncbi.nlm.nih.gov/pubmed/33825710 http://dx.doi.org/10.1107/S2059798321001194

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