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Delirium researchers’ perspectives of the challenges in delirium biomarker research: A qualitative study

BACKGROUND: Despite the prevalence and impact of delirium, its pathophysiology remains unclear. In order to advance this field of research, robust scientific methodology is required, yet quality of reporting in this field of research has been highly inconsistent. Delirium biomarker research poses se...

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Autores principales: Amgarth-Duff, Ingrid, Hosie, Annmarie, Caplan, Gideon A., Agar, Meera
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8026020/
https://www.ncbi.nlm.nih.gov/pubmed/33826629
http://dx.doi.org/10.1371/journal.pone.0243254
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author Amgarth-Duff, Ingrid
Hosie, Annmarie
Caplan, Gideon A.
Agar, Meera
author_facet Amgarth-Duff, Ingrid
Hosie, Annmarie
Caplan, Gideon A.
Agar, Meera
author_sort Amgarth-Duff, Ingrid
collection PubMed
description BACKGROUND: Despite the prevalence and impact of delirium, its pathophysiology remains unclear. In order to advance this field of research, robust scientific methodology is required, yet quality of reporting in this field of research has been highly inconsistent. Delirium biomarker research poses several challenges, none of which have been documented in the literature before. The aim of this study was to explore the perspectives of delirium researchers about key methodological issues in delirium biomarker research. METHODS: Following a Delphi study with delirium experts resulting in 60 recommendations for reporting delirium biomarker studies, semi-structured interviews with international delirium researchers were conducted. Interviews were audio-taped and transcribed verbatim, followed by thematic analysis of the qualitative data. RESULTS: Fifteen participants were interviewed between August and November 2019. Most were male (n = 12; 75%), clinician researchers (n = 13; 86%), and had more than ten years’ experience in conducting delirium research (n = 9; 60%). Analysis revealed two major themes and ten sub-themes, outlining key considerations to advance the field of delirium biomarker research. The major themes were: 1) Practical and scientific challenges of delirium biomarker research: stagnation versus driving improved methods and reporting; and 2) Valuing delirium research through investment and collaboration. CONCLUSION: Findings identified a range of factors that contribute to the practical and ethical challenges of conducting delirium biomarker research, which have not previously been explicitly acknowledged or reported. A clear vision for collaborative efforts to enhance research quality for improved impact was also presented by the delirium researchers. This work complements the preceding Delphi and together these studies provide an in-depth understanding of what is needed in the field to inform and improve methods and reporting of delirium biomarker research.
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spelling pubmed-80260202021-04-15 Delirium researchers’ perspectives of the challenges in delirium biomarker research: A qualitative study Amgarth-Duff, Ingrid Hosie, Annmarie Caplan, Gideon A. Agar, Meera PLoS One Research Article BACKGROUND: Despite the prevalence and impact of delirium, its pathophysiology remains unclear. In order to advance this field of research, robust scientific methodology is required, yet quality of reporting in this field of research has been highly inconsistent. Delirium biomarker research poses several challenges, none of which have been documented in the literature before. The aim of this study was to explore the perspectives of delirium researchers about key methodological issues in delirium biomarker research. METHODS: Following a Delphi study with delirium experts resulting in 60 recommendations for reporting delirium biomarker studies, semi-structured interviews with international delirium researchers were conducted. Interviews were audio-taped and transcribed verbatim, followed by thematic analysis of the qualitative data. RESULTS: Fifteen participants were interviewed between August and November 2019. Most were male (n = 12; 75%), clinician researchers (n = 13; 86%), and had more than ten years’ experience in conducting delirium research (n = 9; 60%). Analysis revealed two major themes and ten sub-themes, outlining key considerations to advance the field of delirium biomarker research. The major themes were: 1) Practical and scientific challenges of delirium biomarker research: stagnation versus driving improved methods and reporting; and 2) Valuing delirium research through investment and collaboration. CONCLUSION: Findings identified a range of factors that contribute to the practical and ethical challenges of conducting delirium biomarker research, which have not previously been explicitly acknowledged or reported. A clear vision for collaborative efforts to enhance research quality for improved impact was also presented by the delirium researchers. This work complements the preceding Delphi and together these studies provide an in-depth understanding of what is needed in the field to inform and improve methods and reporting of delirium biomarker research. Public Library of Science 2021-04-07 /pmc/articles/PMC8026020/ /pubmed/33826629 http://dx.doi.org/10.1371/journal.pone.0243254 Text en © 2021 Amgarth-Duff et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Amgarth-Duff, Ingrid
Hosie, Annmarie
Caplan, Gideon A.
Agar, Meera
Delirium researchers’ perspectives of the challenges in delirium biomarker research: A qualitative study
title Delirium researchers’ perspectives of the challenges in delirium biomarker research: A qualitative study
title_full Delirium researchers’ perspectives of the challenges in delirium biomarker research: A qualitative study
title_fullStr Delirium researchers’ perspectives of the challenges in delirium biomarker research: A qualitative study
title_full_unstemmed Delirium researchers’ perspectives of the challenges in delirium biomarker research: A qualitative study
title_short Delirium researchers’ perspectives of the challenges in delirium biomarker research: A qualitative study
title_sort delirium researchers’ perspectives of the challenges in delirium biomarker research: a qualitative study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8026020/
https://www.ncbi.nlm.nih.gov/pubmed/33826629
http://dx.doi.org/10.1371/journal.pone.0243254
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