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IKAROS is required for the measured response of NOTCH target genes upon external NOTCH signaling

The tumor suppressor IKAROS binds and represses multiple NOTCH target genes. For their induction upon NOTCH signaling, IKAROS is removed and replaced by NOTCH Intracellular Domain (NICD)-associated proteins. However, IKAROS remains associated to other NOTCH activated genes upon signaling and inducti...

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Detalles Bibliográficos
Autores principales:	Lemarié, Maud, Bottardi, Stefania, Mavoungou, Lionel, Pak, Helen, Milot, Eric
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8026084/ https://www.ncbi.nlm.nih.gov/pubmed/33770102 http://dx.doi.org/10.1371/journal.pgen.1009478

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