AMPK/ULK1-mediated phosphorylation of Parkin ACT domain mediates an early step in mitophagy

The serine/threonine kinase ULK1 mediates autophagy initiation in response to various cellular stresses, and genetic deletion of ULK1 leads to accumulation of damaged mitochondria. Here we identify Parkin, the core ubiquitin ligase in mitophagy, and PARK2 gene product mutated in familial Parkinson’s...

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Detalles Bibliográficos
Autores principales: Hung, Chien-Min, Lombardo, Portia S., Malik, Nazma, Brun, Sonja N., Hellberg, Kristina, Van Nostrand, Jeanine L., Garcia, Daniel, Baumgart, Joshua, Diffenderfer, Ken, Asara, John M., Shaw, Reuben J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8026119/
https://www.ncbi.nlm.nih.gov/pubmed/33827825
http://dx.doi.org/10.1126/sciadv.abg4544

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8026119/
https://www.ncbi.nlm.nih.gov/pubmed/33827825
http://dx.doi.org/10.1126/sciadv.abg4544

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