Posttranslational regulation of FOXA1 by Polycomb and BUB3/USP7 deubiquitin complex in prostate cancer

Forkhead box protein A1 (FOXA1) is essential for androgen-dependent prostate cancer (PCa) growth. However, how FOXA1 levels are regulated remains elusive and its therapeutic targeting proven challenging. Here, we report FOXA1 as a nonhistone substrate of enhancer of zeste homolog 2 (EZH2), which met...

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Detalles Bibliográficos
Autores principales: Park, Su H., Fong, Ka-wing, Kim, Jung, Wang, Fang, Lu, Xiaodong, Lee, Yongik, Brea, Lourdes T., Wadosky, Kristine, Guo, Chunming, Abdulkadir, Sarki A., Crispino, John D., Fang, Deyu, Ntziachristos, Panagiotis, Liu, Xin, Li, Xue, Wan, Yong, Goodrich, David W., Zhao, Jonathan C., Yu, Jindan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8026124/
https://www.ncbi.nlm.nih.gov/pubmed/33827814
http://dx.doi.org/10.1126/sciadv.abe2261

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