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Actin fence therapy with exogenous V12Rac1 protects against acute lung injury
High mortality in acute lung injury (ALI) results from sustained proinflammatory signaling by alveolar receptors, such as TNF-α receptor type 1 (TNFR1). Factors that determine the sustained signaling are not known. Unexpectedly, optical imaging of live alveoli revealed a major TNF-α–induced surge of...
Autores principales: | Gusarova, Galina A., Das, Shonit R., Islam, Mohammad N., Westphalen, Kristin, Jin, Guangchun, Shmarakov, Igor O., Li, Li, Bhattacharya, Sunita, Bhattacharya, Jahar |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Clinical Investigation
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8026177/ https://www.ncbi.nlm.nih.gov/pubmed/33749665 http://dx.doi.org/10.1172/jci.insight.135753 |
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