Actin fence therapy with exogenous V12Rac1 protects against acute lung injury

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High mortality in acute lung injury (ALI) results from sustained proinflammatory signaling by alveolar receptors, such as TNF-α receptor type 1 (TNFR1). Factors that determine the sustained signaling are not known. Unexpectedly, optical imaging of live alveoli revealed a major TNF-α–induced surge of...

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Detalles Bibliográficos
Autores principales: Gusarova, Galina A., Das, Shonit R., Islam, Mohammad N., Westphalen, Kristin, Jin, Guangchun, Shmarakov, Igor O., Li, Li, Bhattacharya, Sunita, Bhattacharya, Jahar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8026177/
https://www.ncbi.nlm.nih.gov/pubmed/33749665
http://dx.doi.org/10.1172/jci.insight.135753
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