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Outcomes of COVID-19 Complications and their Possibilities as Potential Triggers of Stroke
INTRODUCTION: There is limited literature on coronavirus disease 2019 (COVID -19) complications such as thromboembolism, cardiac complications etc. as possible trigger for stroke. Hence, we aim to evaluate the prevalence and outcomes of COVID-19 related cardiovascular complications and secondary inf...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8026256/ https://www.ncbi.nlm.nih.gov/pubmed/33892314 http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2021.105805 |
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author | Patel, Urvish Malik, Preeti Mehta, Deep Rajput, Priyanka Shrivastava, Mashu Naveed, Madiha Urhoghide, Eseosa Martin, Mehwish Somi, Shamima Jaiswal, Richa Patel, Achint Israni, Avantika Singh, Jagmeet Kichloo, Asim Shah, Shamik Lunagariya, Abhishek |
author_facet | Patel, Urvish Malik, Preeti Mehta, Deep Rajput, Priyanka Shrivastava, Mashu Naveed, Madiha Urhoghide, Eseosa Martin, Mehwish Somi, Shamima Jaiswal, Richa Patel, Achint Israni, Avantika Singh, Jagmeet Kichloo, Asim Shah, Shamik Lunagariya, Abhishek |
author_sort | Patel, Urvish |
collection | PubMed |
description | INTRODUCTION: There is limited literature on coronavirus disease 2019 (COVID -19) complications such as thromboembolism, cardiac complications etc. as possible trigger for stroke. Hence, we aim to evaluate the prevalence and outcomes of COVID-19 related cardiovascular complications and secondary infection and their possibility as potential triggers for the stroke. METHODS: Data from observational studies describing the complications [acute cardiac injury (ACI), cardiac arrhythmias (CA), disseminated intravascular coagulation (DIC), septic shock, secondary infection] and outcomes of COVID‐19 hospitalized patients from December 1, 2019 to June 30, 2020, were extracted following PRISMA guidelines. Adverse outcomes defined as intensive care units, oxygen saturation less than 90%, invasive mechanical ventilation, severe disease, and in‐hospital mortality. The odds ratio and 95% confidence interval were obtained, and forest plots were created using random‐effects models. A short review of these complications as triggers of stroke was conducted. RESULTS: 16 studies with 3480 confirmed COVID-19 patients, prevalence of ACI [38%vs5.9%], CA [26%vs5.3%], DIC [4%vs0.74%], septic shock [18%vs0.36%], and infection [30%vs12.5%] was higher among patients with poor outcomes. In meta-analysis, ACI [aOR:9.93(95%CI:3.95–25.00], CA [7.52(3.29–17.18)], DIC [7.36(1.24–43.73)], septic shock [30.12(7.56–120.10)], and infection [10.41(4.47–24.27)] had higher odds of adverse outcomes. Patients hospitalized with acute ischemic stroke and intracerebral hemorrhage, had complications like pulmonary embolism, venous thromboembolism, DIC, etc. and had poor outcomes CONCLUSION: The complications like acute cardiac injury, cardiac arrhythmias, DIC, septic shock, and secondary infection had poor outcomes. Patients with stroke were having history of these complications. Long term monitoring is required in such patients to prevent stroke and mitigate adverse outcomes. |
format | Online Article Text |
id | pubmed-8026256 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Elsevier Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-80262562021-04-08 Outcomes of COVID-19 Complications and their Possibilities as Potential Triggers of Stroke Patel, Urvish Malik, Preeti Mehta, Deep Rajput, Priyanka Shrivastava, Mashu Naveed, Madiha Urhoghide, Eseosa Martin, Mehwish Somi, Shamima Jaiswal, Richa Patel, Achint Israni, Avantika Singh, Jagmeet Kichloo, Asim Shah, Shamik Lunagariya, Abhishek J Stroke Cerebrovasc Dis Article INTRODUCTION: There is limited literature on coronavirus disease 2019 (COVID -19) complications such as thromboembolism, cardiac complications etc. as possible trigger for stroke. Hence, we aim to evaluate the prevalence and outcomes of COVID-19 related cardiovascular complications and secondary infection and their possibility as potential triggers for the stroke. METHODS: Data from observational studies describing the complications [acute cardiac injury (ACI), cardiac arrhythmias (CA), disseminated intravascular coagulation (DIC), septic shock, secondary infection] and outcomes of COVID‐19 hospitalized patients from December 1, 2019 to June 30, 2020, were extracted following PRISMA guidelines. Adverse outcomes defined as intensive care units, oxygen saturation less than 90%, invasive mechanical ventilation, severe disease, and in‐hospital mortality. The odds ratio and 95% confidence interval were obtained, and forest plots were created using random‐effects models. A short review of these complications as triggers of stroke was conducted. RESULTS: 16 studies with 3480 confirmed COVID-19 patients, prevalence of ACI [38%vs5.9%], CA [26%vs5.3%], DIC [4%vs0.74%], septic shock [18%vs0.36%], and infection [30%vs12.5%] was higher among patients with poor outcomes. In meta-analysis, ACI [aOR:9.93(95%CI:3.95–25.00], CA [7.52(3.29–17.18)], DIC [7.36(1.24–43.73)], septic shock [30.12(7.56–120.10)], and infection [10.41(4.47–24.27)] had higher odds of adverse outcomes. Patients hospitalized with acute ischemic stroke and intracerebral hemorrhage, had complications like pulmonary embolism, venous thromboembolism, DIC, etc. and had poor outcomes CONCLUSION: The complications like acute cardiac injury, cardiac arrhythmias, DIC, septic shock, and secondary infection had poor outcomes. Patients with stroke were having history of these complications. Long term monitoring is required in such patients to prevent stroke and mitigate adverse outcomes. Elsevier Inc. 2021-07 2021-04-08 /pmc/articles/PMC8026256/ /pubmed/33892314 http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2021.105805 Text en © 2021 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Patel, Urvish Malik, Preeti Mehta, Deep Rajput, Priyanka Shrivastava, Mashu Naveed, Madiha Urhoghide, Eseosa Martin, Mehwish Somi, Shamima Jaiswal, Richa Patel, Achint Israni, Avantika Singh, Jagmeet Kichloo, Asim Shah, Shamik Lunagariya, Abhishek Outcomes of COVID-19 Complications and their Possibilities as Potential Triggers of Stroke |
title | Outcomes of COVID-19 Complications and their Possibilities as Potential Triggers of Stroke |
title_full | Outcomes of COVID-19 Complications and their Possibilities as Potential Triggers of Stroke |
title_fullStr | Outcomes of COVID-19 Complications and their Possibilities as Potential Triggers of Stroke |
title_full_unstemmed | Outcomes of COVID-19 Complications and their Possibilities as Potential Triggers of Stroke |
title_short | Outcomes of COVID-19 Complications and their Possibilities as Potential Triggers of Stroke |
title_sort | outcomes of covid-19 complications and their possibilities as potential triggers of stroke |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8026256/ https://www.ncbi.nlm.nih.gov/pubmed/33892314 http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2021.105805 |
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