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The emerging association between COVID-19 and acute stroke

Prior to COVID-19, only two human-tropic coronaviruses resulted in epidemics and cerebrovascular disease was rarely reported. Evidence now suggests that 1–6% of hospitalized COVID-19 patients develop stroke. According to some reports, stroke risk is more than sevenfold greater in patients with COVID...

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Autores principales: Stein, Laura K., Mayman, Naomi A., Dhamoon, Mandip S., Fifi, Johanna T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8026270/
https://www.ncbi.nlm.nih.gov/pubmed/33879319
http://dx.doi.org/10.1016/j.tins.2021.03.005
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author Stein, Laura K.
Mayman, Naomi A.
Dhamoon, Mandip S.
Fifi, Johanna T.
author_facet Stein, Laura K.
Mayman, Naomi A.
Dhamoon, Mandip S.
Fifi, Johanna T.
author_sort Stein, Laura K.
collection PubMed
description Prior to COVID-19, only two human-tropic coronaviruses resulted in epidemics and cerebrovascular disease was rarely reported. Evidence now suggests that 1–6% of hospitalized COVID-19 patients develop stroke. According to some reports, stroke risk is more than sevenfold greater in patients with COVID-19 than influenza. Concerningly, outcomes of COVID-19-related stroke are often worse than in stroke patients without COVID-19 from the same cohorts. In this review, we highlight the emerging association between COVID-19 and stroke and discuss putative pathogenetic mechanisms. Etiology of stroke in COVID-19 patients is likely multifactorial, related to coagulopathy, inflammation, platelet activation, and alterations to the vascular endothelium. Significant work remains to be done to better understand the pathogenesis of COVID-19-related stroke and for designing optimal primary and secondary prevention strategies.
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spelling pubmed-80262702021-04-08 The emerging association between COVID-19 and acute stroke Stein, Laura K. Mayman, Naomi A. Dhamoon, Mandip S. Fifi, Johanna T. Trends Neurosci Review Prior to COVID-19, only two human-tropic coronaviruses resulted in epidemics and cerebrovascular disease was rarely reported. Evidence now suggests that 1–6% of hospitalized COVID-19 patients develop stroke. According to some reports, stroke risk is more than sevenfold greater in patients with COVID-19 than influenza. Concerningly, outcomes of COVID-19-related stroke are often worse than in stroke patients without COVID-19 from the same cohorts. In this review, we highlight the emerging association between COVID-19 and stroke and discuss putative pathogenetic mechanisms. Etiology of stroke in COVID-19 patients is likely multifactorial, related to coagulopathy, inflammation, platelet activation, and alterations to the vascular endothelium. Significant work remains to be done to better understand the pathogenesis of COVID-19-related stroke and for designing optimal primary and secondary prevention strategies. Elsevier Ltd. 2021-07 2021-04-08 /pmc/articles/PMC8026270/ /pubmed/33879319 http://dx.doi.org/10.1016/j.tins.2021.03.005 Text en © 2021 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Review
Stein, Laura K.
Mayman, Naomi A.
Dhamoon, Mandip S.
Fifi, Johanna T.
The emerging association between COVID-19 and acute stroke
title The emerging association between COVID-19 and acute stroke
title_full The emerging association between COVID-19 and acute stroke
title_fullStr The emerging association between COVID-19 and acute stroke
title_full_unstemmed The emerging association between COVID-19 and acute stroke
title_short The emerging association between COVID-19 and acute stroke
title_sort emerging association between covid-19 and acute stroke
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8026270/
https://www.ncbi.nlm.nih.gov/pubmed/33879319
http://dx.doi.org/10.1016/j.tins.2021.03.005
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