Sensitive protein alignments at tree-of-life scale using DIAMOND

We are at the beginning of a genomic revolution in which all known species are planned to be sequenced. Accessing such data for comparative analyses is crucial in this new age of data-driven biology. Here, we introduce an improved version of DIAMOND that greatly exceeds previous search performances...

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Detalles Bibliográficos
Autores principales: Buchfink, Benjamin, Reuter, Klaus, Drost, Hajk-Georg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2021
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8026399/
https://www.ncbi.nlm.nih.gov/pubmed/33828273
http://dx.doi.org/10.1038/s41592-021-01101-x
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author Buchfink, Benjamin
Reuter, Klaus
Drost, Hajk-Georg
author_facet Buchfink, Benjamin
Reuter, Klaus
Drost, Hajk-Georg
author_sort Buchfink, Benjamin
collection PubMed
description We are at the beginning of a genomic revolution in which all known species are planned to be sequenced. Accessing such data for comparative analyses is crucial in this new age of data-driven biology. Here, we introduce an improved version of DIAMOND that greatly exceeds previous search performances and harnesses supercomputing to perform tree-of-life scale protein alignments in hours, while matching the sensitivity of the gold standard BLASTP.
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spelling pubmed-80263992021-04-27 Sensitive protein alignments at tree-of-life scale using DIAMOND Buchfink, Benjamin Reuter, Klaus Drost, Hajk-Georg Nat Methods Brief Communication We are at the beginning of a genomic revolution in which all known species are planned to be sequenced. Accessing such data for comparative analyses is crucial in this new age of data-driven biology. Here, we introduce an improved version of DIAMOND that greatly exceeds previous search performances and harnesses supercomputing to perform tree-of-life scale protein alignments in hours, while matching the sensitivity of the gold standard BLASTP. Nature Publishing Group US 2021-04-07 2021 /pmc/articles/PMC8026399/ /pubmed/33828273 http://dx.doi.org/10.1038/s41592-021-01101-x Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Brief Communication
Buchfink, Benjamin
Reuter, Klaus
Drost, Hajk-Georg
Sensitive protein alignments at tree-of-life scale using DIAMOND
title Sensitive protein alignments at tree-of-life scale using DIAMOND
title_full Sensitive protein alignments at tree-of-life scale using DIAMOND
title_fullStr Sensitive protein alignments at tree-of-life scale using DIAMOND
title_full_unstemmed Sensitive protein alignments at tree-of-life scale using DIAMOND
title_short Sensitive protein alignments at tree-of-life scale using DIAMOND
title_sort sensitive protein alignments at tree-of-life scale using diamond
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8026399/
https://www.ncbi.nlm.nih.gov/pubmed/33828273
http://dx.doi.org/10.1038/s41592-021-01101-x
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