Cargando…

Osmium–arene complexes with high potency towards Mycobacterium tuberculosis

The treatment of tuberculosis (TB) poses a major challenge as frontline therapeutic agents become increasingly ineffective with the emergence and spread of drug-resistant strains of Mycobacterium tuberculosis (Mtb). To combat this global health problem, new antitubercular agents with novel modes of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Coverdale, James P C, Guy, Collette S, Bridgewater, Hannah E, Needham, Russell J, Fullam, Elizabeth, Sadler, Peter J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8026400/ https://www.ncbi.nlm.nih.gov/pubmed/33693931 http://dx.doi.org/10.1093/mtomcs/mfab007

Ejemplares similares

Tracking Reactions of Asymmetric Organo‐Osmium Transfer Hydrogenation Catalysts in Cancer Cells
por: Bolitho, Elizabeth M., et al.
Publicado: (2021)

In Vivo Selectivity and Localization of Reactive Oxygen Species (ROS) Induction by Osmium Anticancer Complexes That Circumvent Platinum Resistance
por: Coverdale, James P. C., et al.
Publicado: (2018)

Half-Sandwich Arene Ruthenium(II) and Osmium(II) Thiosemicarbazone Complexes: Solution Behavior and Antiproliferative Activity
por: Gatti, Anna, et al.
Publicado: (2018)

Mirror-Image Organometallic Osmium Arene Iminopyridine Halido Complexes Exhibit Similar Potent Anticancer Activity
por: Fu, Ying, et al.
Publicado: (2013)

In‐Cell Activation of Organo‐Osmium(II) Anticancer Complexes
por: Needham, Russell J., et al.
Publicado: (2016)

Dose- and time-dependent tolerability and efficacy of organo-osmium complex FY26 and its tissue pharmacokinetics in hepatocarcinoma-bearing mice
por: Kumar, Swati A, et al.
Publicado: (2020)

Easy To Synthesize, Robust Organo‐osmium Asymmetric Transfer Hydrogenation Catalysts
por: Coverdale, James P. C., et al.
Publicado: (2015)

Osmium Arene Germyl, Stannyl, Germanate, and Stannate Complexes as Anticancer Agents
por: Nabiyeva, Tomiris, et al.
Publicado: (2021)

NMR studies of group 8 metallodrugs: (187)Os-enriched organo-osmium half-sandwich anticancer complex
por: Needham, Russell J., et al.
Publicado: (2021)

Targeting extracellular glycans: tuning multimeric boronic acids for pathogen-selective killing of Mycobacterium tuberculosis
por: Guy, Collette S., et al.
Publicado: (2019)

Halide Control of N,N-Coordination versus N,C-Cyclometalation and Stereospecific Phenyl Ring Deuteration of Osmium(II) p-Cymene Phenylazobenzothiazole Complexes
por: Needham, Russell J., et al.
Publicado: (2017)

Biological activity of ruthenium and osmium arene complexes with modified paullones in human cancer cells
por: Mühlgassner, Gerhard, et al.
Publicado: (2012)

Structural Basis of Glycerophosphodiester Recognition by the Mycobacterium tuberculosis Substrate-Binding Protein UgpB
por: Fenn, Jonathan S., et al.
Publicado: (2019)

Structural and functional determination of homologs of the Mycobacterium tuberculosis N-acetylglucosamine-6-phosphate deacetylase (NagA)
por: Ahangar, Mohd Syed, et al.
Publicado: (2018)

Physicochemical properties and Mycobacterium tuberculosis transporters: keys to efficacious antitubercular drugs?
por: Fullam, Elizabeth, et al.
Publicado: (2020)

Ruthenium− and Osmium−Arene Complexes of 2-Substituted Indolo[3,2-c]quinolines: Synthesis, Structure, Spectroscopic Properties, and Antiproliferative Activity
por: Filak, Lukas K., et al.
Publicado: (2010)

Targeting cancer lactate metabolism with synergistic combinations of synthetic catalysts and monocarboxylate transporter inhibitors
por: Bridgewater, Hannah E., et al.
Publicado: (2023)

Towards Water Soluble Mitochondria-Targeting Theranostic Osmium(II) Triazole-Based Complexes
por: Omar, Salem A. E., et al.
Publicado: (2016)

Antagonizing STAT5B dimerization with an osmium complex
por: Liu, Li-Juan, et al.
Publicado: (2016)

Ruthenium- and osmium-arene complexes of 8-substituted indolo[3,2-c]quinolines: Synthesis, X-ray diffraction structures, spectroscopic properties, and antiproliferative activity
por: Filak, Lukas K., et al.
Publicado: (2012)

Synchrotron X‐Ray Fluorescence Nanoprobe Reveals Target Sites for Organo‐Osmium Complex in Human Ovarian Cancer Cells
por: Sanchez‐Cano, Carlos, et al.
Publicado: (2017)

On-Chip DNA Methylation Analysis Using Osmium Complexation
por: Sugizaki, Kaori, et al.
Publicado: (2011)

An osmium-peroxo complex for photoactive therapy of hypoxic tumors
por: Lu, Nong, et al.
Publicado: (2022)

Structure and function of the transketolase from Mycobacterium tuberculosis and comparison with the human enzyme
por: Fullam, Elizabeth, et al.
Publicado: (2012)

An osmium(II) methane complex: Elucidation of the methane coordination mode
por: Sempsrott, Peter J., et al.
Publicado: (2023)

Vapor Pressures of Ruthenium and Osmium
por: Carrera, N. J., et al.
Publicado: (1964)

Intracellular Photophysics of an Osmium Complex bearing an Oligothiophene Extended Ligand
por: Schneider, Kilian R. A., et al.
Publicado: (2020)

Structural and functional analysis of the solute-binding protein UspC from Mycobacterium tuberculosis that is specific for amino sugars
por: Fullam, Elizabeth, et al.
Publicado: (2016)

Osmium: An Appraisal of Environmental Exposure
por: Smith, Ivan C., et al.
Publicado: (1974)

Injections of Osmium Acid in Neuralgia
Publicado: (1886)

Metal–Arene Complexes with Indolo[3,2-c]-quinolines: Effects of Ruthenium vs Osmium and Modifications of the Lactam Unit on Intermolecular Interactions, Anticancer Activity, Cell Cycle, and Cellular Accumulation
por: Filak, Lukas K., et al.
Publicado: (2013)

Effect of the Piperazine Unit and Metal-Binding Site Position on the Solubility and Anti-Proliferative Activity of Ruthenium(II)- and Osmium(II)- Arene Complexes of Isomeric Indolo[3,2-c]quinoline—Piperazine Hybrids
por: Filak, Lukas K., et al.
Publicado: (2014)

Investigation of Luminescence Characteristics of Osmium(II) Complexes in the Presence of Heparin Polyanions
por: Xie, Yixi, et al.
Publicado: (2013)

Biological properties of novel ruthenium- and osmium-nitrosyl complexes with azole heterocycles
por: Novak, Maria S., et al.
Publicado: (2016)

Identification of cyclic hexapeptides natural products with inhibitory potency against Mycobacterium tuberculosis
por: Singh, Sheo B., et al.
Publicado: (2018)

Actin filament destruction by osmium tetroxide
Publicado: (1978)

A Dual Read-Out Assay to Evaluate the Potency of Compounds Active against Mycobacterium tuberculosis
por: Ollinger, Juliane, et al.
Publicado: (2013)

Striking Difference in Antiproliferative Activity of Ruthenium- and Osmium-Nitrosyl Complexes with Azole Heterocycles
por: Büchel, Gabriel E., et al.
Publicado: (2013)

Radiosensitisation of human colorectal cancer cells by ruthenium(II) arene anticancer complexes
por: Carter, R, et al.
Publicado: (2016)

Light Triggers the Antiproliferative Activity of Naphthalimide-Conjugated (η(6)-arene)ruthenium(II) Complexes
por: Bisceglie, Franco, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_cero0ge5k4m2hjqa8gqv43vqbn