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Extrapolation of pharmacokinetics and pharmacodynamics of sunitinib in children with gastrointestinal stromal tumors

PURPOSE: The starting dose of sunitinib in children with gastrointestinal stromal tumors (GIST) was extrapolated based on data in adults with GIST or solid tumors and children with solid tumors. METHODS: Integrated population pharmacokinetics (PK), PK/pharmacodynamics (PD), and exposure–response ana...

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Detalles Bibliográficos
Autores principales:	Khosravan, Reza, DuBois, Steven G., Janeway, Katherine, Wang, Erjian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2021
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8026416/ https://www.ncbi.nlm.nih.gov/pubmed/33507338 http://dx.doi.org/10.1007/s00280-020-04221-x

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