Potentiation of NETs release is novel characteristic of TREM-1 activation and the pharmacological inhibition of TREM-1 could prevent from the deleterious consequences of NETs release in sepsis

During sepsis, neutrophil activation induces endothelial cell (EC) dysfunction partly through neutrophil extracellular trap (NET) release. The triggering receptor expressed on myeloid cell-1 (TREM-1) is an orphan immune receptor that amplifies the inflammatory response mediated by Toll-like receptor...

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Detalles Bibliográficos
Autores principales: Boufenzer, Amir, Carrasco, Kevin, Jolly, Lucie, Brustolin, Benjamin, Di-Pillo, Elisa, Derive, Marc, Gibot, Sébastien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8026640/
https://www.ncbi.nlm.nih.gov/pubmed/33420354
http://dx.doi.org/10.1038/s41423-020-00591-7

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