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First Movers in Molecular Detection: Case Comparison on Harnessing Research and Development, Industry, and Entrepreneurship

The current unprecedented COVID-19 pandemic underscores the importance of diagnostic assays in health security preparedness and readiness. Advancing new technologies for rapid molecular detection of high consequence infectious pathogens is an ongoing challenge that requires ingenuity and vision. Sus...

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Autores principales: Yeh, Kenneth B., Scullion, Matt, Michelotti, Julia M., Olinger, Gene
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8026858/
https://www.ncbi.nlm.nih.gov/pubmed/33842501
http://dx.doi.org/10.3389/fmed.2021.639440
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author Yeh, Kenneth B.
Scullion, Matt
Michelotti, Julia M.
Olinger, Gene
author_facet Yeh, Kenneth B.
Scullion, Matt
Michelotti, Julia M.
Olinger, Gene
author_sort Yeh, Kenneth B.
collection PubMed
description The current unprecedented COVID-19 pandemic underscores the importance of diagnostic assays in health security preparedness and readiness. Advancing new technologies for rapid molecular detection of high consequence infectious pathogens is an ongoing challenge that requires ingenuity and vision. Sustainment of a robust supply chain for materials and the logistics of timely product delivery further challenge diagnostic kit and device manufacturers. Business economists often characterize technology companies that discover unique breakthroughs in their field and are first to bring related products to market as first movers. From a market perspective, three first mover characteristics include: having the knowledge and capability to address a unique breakthrough, excellent technological leadership, and the ability to capitalize on the opportunity. Current mainstays for molecular detection include using Taq DNA Polymerase enzyme and fluorescent chemistry for quantitative PCR (qPCR). A newer and promising technology uses CRISPR-Cas proteins for nucleic acid detection. Our panel discussion from the 2020 ASM Biothreats conference, which included members from two prototypical first mover companies, explored their respective corporate experiences. Both companies were selected for the discussion based on their revolutionary innovations and similarities in their research and development, corporate culture and trajectory. One company, established over 20 years ago, became a market leader in the biothreat detection market by advancing air thermocycling qPCR across multiple product families. The second company is a rapidly growing start-up and a scientific pioneer in establishing next generation CRISPR technologies. Here we discuss their technology development, product deployment, and customer markets to draw lessons learned for researchers, end users, and funders.
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spelling pubmed-80268582021-04-09 First Movers in Molecular Detection: Case Comparison on Harnessing Research and Development, Industry, and Entrepreneurship Yeh, Kenneth B. Scullion, Matt Michelotti, Julia M. Olinger, Gene Front Med (Lausanne) Medicine The current unprecedented COVID-19 pandemic underscores the importance of diagnostic assays in health security preparedness and readiness. Advancing new technologies for rapid molecular detection of high consequence infectious pathogens is an ongoing challenge that requires ingenuity and vision. Sustainment of a robust supply chain for materials and the logistics of timely product delivery further challenge diagnostic kit and device manufacturers. Business economists often characterize technology companies that discover unique breakthroughs in their field and are first to bring related products to market as first movers. From a market perspective, three first mover characteristics include: having the knowledge and capability to address a unique breakthrough, excellent technological leadership, and the ability to capitalize on the opportunity. Current mainstays for molecular detection include using Taq DNA Polymerase enzyme and fluorescent chemistry for quantitative PCR (qPCR). A newer and promising technology uses CRISPR-Cas proteins for nucleic acid detection. Our panel discussion from the 2020 ASM Biothreats conference, which included members from two prototypical first mover companies, explored their respective corporate experiences. Both companies were selected for the discussion based on their revolutionary innovations and similarities in their research and development, corporate culture and trajectory. One company, established over 20 years ago, became a market leader in the biothreat detection market by advancing air thermocycling qPCR across multiple product families. The second company is a rapidly growing start-up and a scientific pioneer in establishing next generation CRISPR technologies. Here we discuss their technology development, product deployment, and customer markets to draw lessons learned for researchers, end users, and funders. Frontiers Media S.A. 2021-03-25 /pmc/articles/PMC8026858/ /pubmed/33842501 http://dx.doi.org/10.3389/fmed.2021.639440 Text en Copyright © 2021 Yeh, Scullion, Michelotti and Olinger. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Yeh, Kenneth B.
Scullion, Matt
Michelotti, Julia M.
Olinger, Gene
First Movers in Molecular Detection: Case Comparison on Harnessing Research and Development, Industry, and Entrepreneurship
title First Movers in Molecular Detection: Case Comparison on Harnessing Research and Development, Industry, and Entrepreneurship
title_full First Movers in Molecular Detection: Case Comparison on Harnessing Research and Development, Industry, and Entrepreneurship
title_fullStr First Movers in Molecular Detection: Case Comparison on Harnessing Research and Development, Industry, and Entrepreneurship
title_full_unstemmed First Movers in Molecular Detection: Case Comparison on Harnessing Research and Development, Industry, and Entrepreneurship
title_short First Movers in Molecular Detection: Case Comparison on Harnessing Research and Development, Industry, and Entrepreneurship
title_sort first movers in molecular detection: case comparison on harnessing research and development, industry, and entrepreneurship
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8026858/
https://www.ncbi.nlm.nih.gov/pubmed/33842501
http://dx.doi.org/10.3389/fmed.2021.639440
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