Drosophila RASopathy models identify disease subtype differences and biomarkers of drug efficacy

RASopathies represent a family of mostly autosomal dominant diseases that are caused by missense variants in the rat sarcoma viral oncogene/mitogen activated protein kinase (RAS/MAPK) pathway including KRAS, NRAS, BRAF, RAF1, and SHP2. These variants are associated with overlapping but distinct phen...

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Detalles Bibliográficos
Autores principales: Das, Tirtha K., Gatto, Jared, Mirmira, Rupa, Hourizadeh, Ethan, Kaufman, Dalia, Gelb, Bruce D., Cagan, Ross
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8026909/
https://www.ncbi.nlm.nih.gov/pubmed/33855281
http://dx.doi.org/10.1016/j.isci.2021.102306

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8026909/
https://www.ncbi.nlm.nih.gov/pubmed/33855281
http://dx.doi.org/10.1016/j.isci.2021.102306

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