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XRCC5/6 polymorphisms and their interactions with smoking, alcohol consumption, and sleep satisfaction in breast cancer risk: A Chinese multi‐center study

BACKGROUND: X‐ray repair cross‐complementary 5 (XRCC5) and 6 (XRCC6) are critical for DNA repair. Few studies have assessed their association with breast cancer risk, and related gene‐environment interactions remain poorly understood. This study aimed to determine the influence of XRCC5/6 polymorphi...

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Autores principales: Yu, Li‐Xiang, Liu, Li‐Yuan, Xiang, Yu‐Juan, Wang, Fei, Zhou, Fei, Huang, Shu‐Ya, Zheng, Chao, Ye, Chun‐Miao, Zhou, Wen‐Zhong, Yin, Geng‐Shen, Zhang, Jia‐Lin, Cui, Shu‐De, Tian, Fu‐Guo, Fan, Zhi‐Min, Geng, Cui‐Zhi, Cao, Xu‐Chen, Yang, Zhen‐Lin, Wang, Xiang, Liang, Hong, Wang, Shu, Jiang, Hong‐Chuan, Duan, Xue‐Ning, Wang, Hai‐Bo, Li, Guo‐Lou, Wang, Qi‐Tang, Zhang, Jian‐Guo, Jin, Feng, Tang, Jin‐Hai, Li, Liang, Zhu, Shi‐Guang, Zuo, Wen‐Shu, Ma, Zhong‐Bing, Yu, Zhi‐Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8026916/
https://www.ncbi.nlm.nih.gov/pubmed/33734613
http://dx.doi.org/10.1002/cam4.3847
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author Yu, Li‐Xiang
Liu, Li‐Yuan
Xiang, Yu‐Juan
Wang, Fei
Zhou, Fei
Huang, Shu‐Ya
Zheng, Chao
Ye, Chun‐Miao
Zhou, Wen‐Zhong
Yin, Geng‐Shen
Zhang, Jia‐Lin
Cui, Shu‐De
Tian, Fu‐Guo
Fan, Zhi‐Min
Geng, Cui‐Zhi
Cao, Xu‐Chen
Yang, Zhen‐Lin
Wang, Xiang
Liang, Hong
Wang, Shu
Jiang, Hong‐Chuan
Duan, Xue‐Ning
Wang, Hai‐Bo
Li, Guo‐Lou
Wang, Qi‐Tang
Zhang, Jian‐Guo
Jin, Feng
Tang, Jin‐Hai
Li, Liang
Zhu, Shi‐Guang
Zuo, Wen‐Shu
Ma, Zhong‐Bing
Yu, Zhi‐Gang
author_facet Yu, Li‐Xiang
Liu, Li‐Yuan
Xiang, Yu‐Juan
Wang, Fei
Zhou, Fei
Huang, Shu‐Ya
Zheng, Chao
Ye, Chun‐Miao
Zhou, Wen‐Zhong
Yin, Geng‐Shen
Zhang, Jia‐Lin
Cui, Shu‐De
Tian, Fu‐Guo
Fan, Zhi‐Min
Geng, Cui‐Zhi
Cao, Xu‐Chen
Yang, Zhen‐Lin
Wang, Xiang
Liang, Hong
Wang, Shu
Jiang, Hong‐Chuan
Duan, Xue‐Ning
Wang, Hai‐Bo
Li, Guo‐Lou
Wang, Qi‐Tang
Zhang, Jian‐Guo
Jin, Feng
Tang, Jin‐Hai
Li, Liang
Zhu, Shi‐Guang
Zuo, Wen‐Shu
Ma, Zhong‐Bing
Yu, Zhi‐Gang
author_sort Yu, Li‐Xiang
collection PubMed
description BACKGROUND: X‐ray repair cross‐complementary 5 (XRCC5) and 6 (XRCC6) are critical for DNA repair. Few studies have assessed their association with breast cancer risk, and related gene‐environment interactions remain poorly understood. This study aimed to determine the influence of XRCC5/6 polymorphisms on breast cancer risk, and their interactions with cigarette smoking, alcohol consumption, and sleep satisfaction. METHODS: The study included 1039 patients with breast cancer and 1040 controls. Four single‐nucleotide polymorphisms of XRCC5 and two of XRCC6 were genotyped. Information about smoking, alcohol consumption, and sleep satisfaction was collected through questionnaires. Odds ratios (OR) and related 95% confidence intervals (95% CI) were assessed using unconditional logistic regression models. Gene‐environment interactions were analyzed using logistic regression with multiplicative interaction models. RESULTS: XRCC5 rs16855458 was associated with increased breast cancer risk in the co‐dominant (p (trend) = 0.003) and dominant (CA + AA vs. CC, OR = 1.29, 95% CI = 1.07–1.56, p = 0.008) genetic models after Bonferroni correction. The CG + GG genotype of XRCC6 rs2267437 was associated with an increased risk of estrogen receptor‐negative/progesterone receptor‐negative (ER−/PR−) breast cancer (CG + GG vs. CC: OR = 1.54, 95% CI = 1.12–2.13, p = 0.008) after Bonferroni correction. Moreover, an antagonistic interaction between XRCC5 rs16855458 and alcohol consumption (p (interaction) = 0.017), and a synergistic interaction between XRCC6 rs2267437 and sleep satisfaction were associated with breast cancer risk (p (interaction) = 0.0497). However, these interactions became insignificant after Bonferroni correction. CONCLUSION: XRCC5 rs16855458 was associated with breast cancer risk, and XRCC6 rs2267437 was associated with the risk of ER−/PR− breast cancer. Breast cancer risk associated with XRCC5 and XRCC6 polymorphisms might vary according to alcohol consumption and sleep satisfaction, respectively, and merit further investigation.
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spelling pubmed-80269162021-04-13 XRCC5/6 polymorphisms and their interactions with smoking, alcohol consumption, and sleep satisfaction in breast cancer risk: A Chinese multi‐center study Yu, Li‐Xiang Liu, Li‐Yuan Xiang, Yu‐Juan Wang, Fei Zhou, Fei Huang, Shu‐Ya Zheng, Chao Ye, Chun‐Miao Zhou, Wen‐Zhong Yin, Geng‐Shen Zhang, Jia‐Lin Cui, Shu‐De Tian, Fu‐Guo Fan, Zhi‐Min Geng, Cui‐Zhi Cao, Xu‐Chen Yang, Zhen‐Lin Wang, Xiang Liang, Hong Wang, Shu Jiang, Hong‐Chuan Duan, Xue‐Ning Wang, Hai‐Bo Li, Guo‐Lou Wang, Qi‐Tang Zhang, Jian‐Guo Jin, Feng Tang, Jin‐Hai Li, Liang Zhu, Shi‐Guang Zuo, Wen‐Shu Ma, Zhong‐Bing Yu, Zhi‐Gang Cancer Med Clinical Cancer Research BACKGROUND: X‐ray repair cross‐complementary 5 (XRCC5) and 6 (XRCC6) are critical for DNA repair. Few studies have assessed their association with breast cancer risk, and related gene‐environment interactions remain poorly understood. This study aimed to determine the influence of XRCC5/6 polymorphisms on breast cancer risk, and their interactions with cigarette smoking, alcohol consumption, and sleep satisfaction. METHODS: The study included 1039 patients with breast cancer and 1040 controls. Four single‐nucleotide polymorphisms of XRCC5 and two of XRCC6 were genotyped. Information about smoking, alcohol consumption, and sleep satisfaction was collected through questionnaires. Odds ratios (OR) and related 95% confidence intervals (95% CI) were assessed using unconditional logistic regression models. Gene‐environment interactions were analyzed using logistic regression with multiplicative interaction models. RESULTS: XRCC5 rs16855458 was associated with increased breast cancer risk in the co‐dominant (p (trend) = 0.003) and dominant (CA + AA vs. CC, OR = 1.29, 95% CI = 1.07–1.56, p = 0.008) genetic models after Bonferroni correction. The CG + GG genotype of XRCC6 rs2267437 was associated with an increased risk of estrogen receptor‐negative/progesterone receptor‐negative (ER−/PR−) breast cancer (CG + GG vs. CC: OR = 1.54, 95% CI = 1.12–2.13, p = 0.008) after Bonferroni correction. Moreover, an antagonistic interaction between XRCC5 rs16855458 and alcohol consumption (p (interaction) = 0.017), and a synergistic interaction between XRCC6 rs2267437 and sleep satisfaction were associated with breast cancer risk (p (interaction) = 0.0497). However, these interactions became insignificant after Bonferroni correction. CONCLUSION: XRCC5 rs16855458 was associated with breast cancer risk, and XRCC6 rs2267437 was associated with the risk of ER−/PR− breast cancer. Breast cancer risk associated with XRCC5 and XRCC6 polymorphisms might vary according to alcohol consumption and sleep satisfaction, respectively, and merit further investigation. John Wiley and Sons Inc. 2021-03-18 /pmc/articles/PMC8026916/ /pubmed/33734613 http://dx.doi.org/10.1002/cam4.3847 Text en © 2021 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Cancer Research
Yu, Li‐Xiang
Liu, Li‐Yuan
Xiang, Yu‐Juan
Wang, Fei
Zhou, Fei
Huang, Shu‐Ya
Zheng, Chao
Ye, Chun‐Miao
Zhou, Wen‐Zhong
Yin, Geng‐Shen
Zhang, Jia‐Lin
Cui, Shu‐De
Tian, Fu‐Guo
Fan, Zhi‐Min
Geng, Cui‐Zhi
Cao, Xu‐Chen
Yang, Zhen‐Lin
Wang, Xiang
Liang, Hong
Wang, Shu
Jiang, Hong‐Chuan
Duan, Xue‐Ning
Wang, Hai‐Bo
Li, Guo‐Lou
Wang, Qi‐Tang
Zhang, Jian‐Guo
Jin, Feng
Tang, Jin‐Hai
Li, Liang
Zhu, Shi‐Guang
Zuo, Wen‐Shu
Ma, Zhong‐Bing
Yu, Zhi‐Gang
XRCC5/6 polymorphisms and their interactions with smoking, alcohol consumption, and sleep satisfaction in breast cancer risk: A Chinese multi‐center study
title XRCC5/6 polymorphisms and their interactions with smoking, alcohol consumption, and sleep satisfaction in breast cancer risk: A Chinese multi‐center study
title_full XRCC5/6 polymorphisms and their interactions with smoking, alcohol consumption, and sleep satisfaction in breast cancer risk: A Chinese multi‐center study
title_fullStr XRCC5/6 polymorphisms and their interactions with smoking, alcohol consumption, and sleep satisfaction in breast cancer risk: A Chinese multi‐center study
title_full_unstemmed XRCC5/6 polymorphisms and their interactions with smoking, alcohol consumption, and sleep satisfaction in breast cancer risk: A Chinese multi‐center study
title_short XRCC5/6 polymorphisms and their interactions with smoking, alcohol consumption, and sleep satisfaction in breast cancer risk: A Chinese multi‐center study
title_sort xrcc5/6 polymorphisms and their interactions with smoking, alcohol consumption, and sleep satisfaction in breast cancer risk: a chinese multi‐center study
topic Clinical Cancer Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8026916/
https://www.ncbi.nlm.nih.gov/pubmed/33734613
http://dx.doi.org/10.1002/cam4.3847
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