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Time trends of major cancers incidence and mortality in Guangzhou, China 2004–2015: A Joinpoint and Age–Period–Cohort Analysis

BACKGROUND: Cancer is an important focus of public health worldwide. This study aims to provide a comprehensive overview of temporal trends in incidence and mortality of leading cancer in Guangzhou, China from 2004 to 2015. METHODS: Data were collected from the population‐based registry in Guangzhou...

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Autores principales: Luo, Ao, Dong, Hang, Lin, Xiao, Liao, Yu, Liang, Binglun, Chen, Long, Lin, Guozhen, Hao, Yuantao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8026941/
https://www.ncbi.nlm.nih.gov/pubmed/33724715
http://dx.doi.org/10.1002/cam4.3744
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author Luo, Ao
Dong, Hang
Lin, Xiao
Liao, Yu
Liang, Binglun
Chen, Long
Lin, Guozhen
Hao, Yuantao
author_facet Luo, Ao
Dong, Hang
Lin, Xiao
Liao, Yu
Liang, Binglun
Chen, Long
Lin, Guozhen
Hao, Yuantao
author_sort Luo, Ao
collection PubMed
description BACKGROUND: Cancer is an important focus of public health worldwide. This study aims to provide a comprehensive overview of temporal trends in incidence and mortality of leading cancer in Guangzhou, China from 2004 to 2015. METHODS: Data were collected from the population‐based registry in Guangzhou. Age‐standardized incidence rate (ASIR) and age‐standardized mortality rate (ASMR) were calculated and Joinpoint regression was used for evaluating the average annual percent changes (AAPC) among the entire study period and the estimated annual percent changes (EAPC) in time segments. The effects of age, period, and birth cohort were assessed by the age–period–cohort model. RESULTS: The age‐standardized incidence and mortality by the world standard population decreased significantly among males with AAPC of −1.7% (95% CI: −3.0%, 0.2%) and −2.7% (95% CI: −4.3%, −1.1%) for all malignancies during 2004–2015, while among females, the age‐standardized incidence had a non‐significant reduction with AAPC of −1.3% (95% CI: −2.8%, 0.2%) and the age‐standardized mortality demonstrated a remarkable decline (AAPC −2.0%, 95% CI: −3.6%, −0.3%). For males, the most commonly diagnosed cancers were trachea, bronchus, and lung (TBL), liver, colorectal, nasopharyngeal, stomach, and prostate cancer. For females, breast, TBL, colorectal, liver stomach, and thyroid cancer ranked the top. Unfavorable trends were observed in ASIR of colorectal, thyroid, and prostate cancer. APC models yielded different ages, periods, and birth cohort effect patterns by cancer sites. CONCLUSIONS: Cancer burden remained a public health challenge in Guangzhou as the aging population and lifestyles changes, despite declines in incidence and mortality rates in some cancers. Surveillance of cancer trends contributed to valuable insights into cancer prevention and control.
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spelling pubmed-80269412021-04-13 Time trends of major cancers incidence and mortality in Guangzhou, China 2004–2015: A Joinpoint and Age–Period–Cohort Analysis Luo, Ao Dong, Hang Lin, Xiao Liao, Yu Liang, Binglun Chen, Long Lin, Guozhen Hao, Yuantao Cancer Med Cancer Prevention BACKGROUND: Cancer is an important focus of public health worldwide. This study aims to provide a comprehensive overview of temporal trends in incidence and mortality of leading cancer in Guangzhou, China from 2004 to 2015. METHODS: Data were collected from the population‐based registry in Guangzhou. Age‐standardized incidence rate (ASIR) and age‐standardized mortality rate (ASMR) were calculated and Joinpoint regression was used for evaluating the average annual percent changes (AAPC) among the entire study period and the estimated annual percent changes (EAPC) in time segments. The effects of age, period, and birth cohort were assessed by the age–period–cohort model. RESULTS: The age‐standardized incidence and mortality by the world standard population decreased significantly among males with AAPC of −1.7% (95% CI: −3.0%, 0.2%) and −2.7% (95% CI: −4.3%, −1.1%) for all malignancies during 2004–2015, while among females, the age‐standardized incidence had a non‐significant reduction with AAPC of −1.3% (95% CI: −2.8%, 0.2%) and the age‐standardized mortality demonstrated a remarkable decline (AAPC −2.0%, 95% CI: −3.6%, −0.3%). For males, the most commonly diagnosed cancers were trachea, bronchus, and lung (TBL), liver, colorectal, nasopharyngeal, stomach, and prostate cancer. For females, breast, TBL, colorectal, liver stomach, and thyroid cancer ranked the top. Unfavorable trends were observed in ASIR of colorectal, thyroid, and prostate cancer. APC models yielded different ages, periods, and birth cohort effect patterns by cancer sites. CONCLUSIONS: Cancer burden remained a public health challenge in Guangzhou as the aging population and lifestyles changes, despite declines in incidence and mortality rates in some cancers. Surveillance of cancer trends contributed to valuable insights into cancer prevention and control. John Wiley and Sons Inc. 2021-03-16 /pmc/articles/PMC8026941/ /pubmed/33724715 http://dx.doi.org/10.1002/cam4.3744 Text en © 2021 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Cancer Prevention
Luo, Ao
Dong, Hang
Lin, Xiao
Liao, Yu
Liang, Binglun
Chen, Long
Lin, Guozhen
Hao, Yuantao
Time trends of major cancers incidence and mortality in Guangzhou, China 2004–2015: A Joinpoint and Age–Period–Cohort Analysis
title Time trends of major cancers incidence and mortality in Guangzhou, China 2004–2015: A Joinpoint and Age–Period–Cohort Analysis
title_full Time trends of major cancers incidence and mortality in Guangzhou, China 2004–2015: A Joinpoint and Age–Period–Cohort Analysis
title_fullStr Time trends of major cancers incidence and mortality in Guangzhou, China 2004–2015: A Joinpoint and Age–Period–Cohort Analysis
title_full_unstemmed Time trends of major cancers incidence and mortality in Guangzhou, China 2004–2015: A Joinpoint and Age–Period–Cohort Analysis
title_short Time trends of major cancers incidence and mortality in Guangzhou, China 2004–2015: A Joinpoint and Age–Period–Cohort Analysis
title_sort time trends of major cancers incidence and mortality in guangzhou, china 2004–2015: a joinpoint and age–period–cohort analysis
topic Cancer Prevention
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8026941/
https://www.ncbi.nlm.nih.gov/pubmed/33724715
http://dx.doi.org/10.1002/cam4.3744
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