Optimized beam shaping assembly for a 2.1-MeV proton-accelerator-based neutron source for boron neutron capture therapy

Boron Neutron Capture Therapy (BNCT) is facing a new era where different projects based on accelerators instead of reactors are under development. The new facilities can be placed at hospitals and will increase the number of clinical trials. The therapeutic effect of BNCT can be improved if a optimi...

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Autores principales: Torres-Sánchez, Pablo, Porras, Ignacio, Ramos-Chernenko, Nataliya, Arias de Saavedra, Fernando, Praena, Javier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8026976/
https://www.ncbi.nlm.nih.gov/pubmed/33828211
http://dx.doi.org/10.1038/s41598-021-87305-9
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author Torres-Sánchez, Pablo
Porras, Ignacio
Ramos-Chernenko, Nataliya
Arias de Saavedra, Fernando
Praena, Javier
author_facet Torres-Sánchez, Pablo
Porras, Ignacio
Ramos-Chernenko, Nataliya
Arias de Saavedra, Fernando
Praena, Javier
author_sort Torres-Sánchez, Pablo
collection PubMed
description Boron Neutron Capture Therapy (BNCT) is facing a new era where different projects based on accelerators instead of reactors are under development. The new facilities can be placed at hospitals and will increase the number of clinical trials. The therapeutic effect of BNCT can be improved if a optimized epithermal neutron spectrum is obtained, for which the beam shape assembly is a key ingredient. In this paper we propose an optimal beam shaping assembly suited for an affordable low energy accelerator. The beam obtained with the device proposed accomplishes all the IAEA recommendations for proton energies between 2.0 and 2.1 MeV. In addition, there is an overall improvement of the figures of merit with respect to BNCT facilities and previous proposals of new accelerator-based facilities.
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spelling pubmed-80269762021-04-08 Optimized beam shaping assembly for a 2.1-MeV proton-accelerator-based neutron source for boron neutron capture therapy Torres-Sánchez, Pablo Porras, Ignacio Ramos-Chernenko, Nataliya Arias de Saavedra, Fernando Praena, Javier Sci Rep Article Boron Neutron Capture Therapy (BNCT) is facing a new era where different projects based on accelerators instead of reactors are under development. The new facilities can be placed at hospitals and will increase the number of clinical trials. The therapeutic effect of BNCT can be improved if a optimized epithermal neutron spectrum is obtained, for which the beam shape assembly is a key ingredient. In this paper we propose an optimal beam shaping assembly suited for an affordable low energy accelerator. The beam obtained with the device proposed accomplishes all the IAEA recommendations for proton energies between 2.0 and 2.1 MeV. In addition, there is an overall improvement of the figures of merit with respect to BNCT facilities and previous proposals of new accelerator-based facilities. Nature Publishing Group UK 2021-04-07 /pmc/articles/PMC8026976/ /pubmed/33828211 http://dx.doi.org/10.1038/s41598-021-87305-9 Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Torres-Sánchez, Pablo
Porras, Ignacio
Ramos-Chernenko, Nataliya
Arias de Saavedra, Fernando
Praena, Javier
Optimized beam shaping assembly for a 2.1-MeV proton-accelerator-based neutron source for boron neutron capture therapy
title Optimized beam shaping assembly for a 2.1-MeV proton-accelerator-based neutron source for boron neutron capture therapy
title_full Optimized beam shaping assembly for a 2.1-MeV proton-accelerator-based neutron source for boron neutron capture therapy
title_fullStr Optimized beam shaping assembly for a 2.1-MeV proton-accelerator-based neutron source for boron neutron capture therapy
title_full_unstemmed Optimized beam shaping assembly for a 2.1-MeV proton-accelerator-based neutron source for boron neutron capture therapy
title_short Optimized beam shaping assembly for a 2.1-MeV proton-accelerator-based neutron source for boron neutron capture therapy
title_sort optimized beam shaping assembly for a 2.1-mev proton-accelerator-based neutron source for boron neutron capture therapy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8026976/
https://www.ncbi.nlm.nih.gov/pubmed/33828211
http://dx.doi.org/10.1038/s41598-021-87305-9
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