Cargando…

IRE1α-XBP1 Affects the Mitochondrial Function of Aβ25–35-Treated SH-SY5Y Cells by Regulating Mitochondria-Associated Endoplasmic Reticulum Membranes

Background: Neurotoxicity induced by the amyloid beta (Aβ) peptide is one of the most important pathological mechanisms of Alzheimer's disease (AD). Activation of the adaptive IRE1α-XBP1 pathway contributes to the pathogenesis of AD, making it a potential target for AD therapeutics. However, th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chu, Bingcong, Li, Maoyu, Cao, Xi, Li, Rulong, Jin, Suqin, Yang, Hui, Xu, Linlin, Wang, Ping, Bi, Jianzhong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Cellular Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8027129/ https://www.ncbi.nlm.nih.gov/pubmed/33841100 http://dx.doi.org/10.3389/fncel.2021.614556

Ejemplares similares

IRE1/XBP1 and endoplasmic reticulum signaling — from basic to translational research for cardiovascular disease
por: Fu, Fangyi, et al.
Publicado: (2022)

Loss of p53 enhances the function of the endoplasmic reticulum through activation of the IRE1α/XBP1 pathway
por: Namba, Takushi, et al.
Publicado: (2015)

IRE-1-Targeting Caged Prodrug with Endoplasmic Reticulum Stress-Inducing and XBP-1S-Inhibiting Activities for Cancer Therapy
por: Shao, Andong, et al.
Publicado: (2022)

PHLDA3 overexpression in hepatocytes by endoplasmic reticulum stress via IRE1–Xbp1s pathway expedites liver injury
por: Han, Chang Yeob, et al.
Publicado: (2016)

Endoplasmic reticulum stress enhances fibrosis through IRE1α‐mediated degradation of miR‐150 and XBP‐1 splicing
por: Heindryckx, Femke, et al.
Publicado: (2016)

CaMKII orchestrates endoplasmic reticulum stress and apoptosis in doxorubicin‐induced cardiotoxicity by regulating the IRE1α/XBP1s pathway
por: Kong, Lingheng, et al.
Publicado: (2022)

Melatonin promotes sirtuin 1 expression and inhibits IRE1α–XBP1S–CHOP to reduce endoplasmic reticulum stress–mediated apoptosis in chondrocytes
por: Qin, Kunpeng, et al.
Publicado: (2022)

Enhanced IRE1α Phosphorylation/Oligomerization-Triggered XBP1 Splicing Contributes to Parkin-Mediated Prevention of SH-SY5Y Cell Death under Nitrosative Stress
por: Chiu, Tsung-Lang, et al.
Publicado: (2023)

Inhibition of the endoplasmic reticulum (ER) stress-associated IRE-1/XBP-1 pathway alleviates acute lung injury via modulation of macrophage activation
por: Zhao, Yanfeng, et al.
Publicado: (2020)

XBP1 modulates endoplasmic reticulum and mitochondria crosstalk via regulating NLRP3 in renal ischemia/reperfusion injury
por: Ni, Haiqiang, et al.
Publicado: (2023)

Emodin, an Emerging Mycotoxin, Induces Endoplasmic Reticulum Stress-Related Hepatotoxicity through IRE1α–XBP1 Axis in HepG2 Cells
por: Park, Su Been, et al.
Publicado: (2023)

IRE1β negatively regulates IRE1α signaling in response to endoplasmic reticulum stress
por: Grey, Michael J., et al.
Publicado: (2020)

The interaction of S100A16 and GRP78 actives endoplasmic reticulum stress-mediated through the IRE1α/XBP1 pathway in renal tubulointerstitial fibrosis
por: Jin, Runbing, et al.
Publicado: (2021)

PCV2 and PRV Coinfection Induces Endoplasmic Reticulum Stress via PERK-eIF2α-ATF4-CHOP and IRE1-XBP1-EDEM Pathways
por: Chen, Si, et al.
Publicado: (2022)

IRE1α is an endogenous substrate of endoplasmic reticulum-associated degradation
por: Sun, Shengyi, et al.
Publicado: (2015)

XBP1 mitigates aminoglycoside-induced endoplasmic reticulum stress and neuronal cell death
por: Oishi, N, et al.
Publicado: (2015)

Cleavage of BLOC1S1 mRNA by IRE1 Is Sequence Specific, Temporally Separate from XBP1 Splicing, and Dispensable for Cell Viability under Acute Endoplasmic Reticulum Stress
por: Bright, Michael D., et al.
Publicado: (2015)

Moringa oleifera Protects SH-SY5YCells from DEHP-Induced Endoplasmic Reticulum Stress and Apoptosis
por: Amara, Ines, et al.
Publicado: (2021)

Curcumin in Combination with Aerobic Exercise Improves Follicular Dysfunction via Inhibition of the Hyperandrogen-Induced IRE1α/XBP1 Endoplasmic Reticulum Stress Pathway in PCOS-Like Rats
por: Zhang, Yaling, et al.
Publicado: (2021)

Hydroxycarboxylic Acid Receptor 2 Is a Zika Virus Restriction Factor That Can Be Induced by Zika Virus Infection Through the IRE1-XBP1 Pathway
por: Ma, Xiaocao, et al.
Publicado: (2020)

Homeostatic adaptation to endoplasmic reticulum stress depends on Ire1 kinase activity
por: Rubio, Claudia, et al.
Publicado: (2011)

Role of IRE1α/XBP-1 in Cystic Fibrosis Airway Inflammation
por: Ribeiro, Carla M. P., et al.
Publicado: (2017)

IRE1α Promotes Zika Virus Infection via XBP1
por: Kolpikova, Elena P., et al.
Publicado: (2020)

Incorporation of the Endoplasmic Reticulum Stress-Induced Spliced Form of XBP1 mRNA in the Exosomes
por: Hosoi, Toru, et al.
Publicado: (2018)

Astrocyte Pannexin 1 Suppresses LPS-Induced Inflammatory Responses to Protect Neuronal SH-SY5Y Cells
por: Ling, Zhuo-Min, et al.
Publicado: (2021)

EGFR confers radioresistance in human oropharyngeal carcinoma by activating endoplasmic reticulum stress signaling PERK‐eIF2α‐GRP94 and IRE1α‐XBP1‐GRP78
por: Zhang, Miao, et al.
Publicado: (2018)

SARS-CoV-2 Diverges from Other Betacoronaviruses in Only Partially Activating the IRE1α/XBP1 Endoplasmic Reticulum Stress Pathway in Human Lung-Derived Cells
por: Nguyen, Long C., et al.
Publicado: (2022)

UPR Responsive Genes Manf and Xbp1 in Stroke
por: Lõhelaid, Helike, et al.
Publicado: (2022)

Capsaicin Ameliorates the Loosening of Mitochondria-Associated Endoplasmic Reticulum Membranes and Improves Cognitive Function in Rats With Chronic Cerebral Hypoperfusion
por: Ouyang, Mengqi, et al.
Publicado: (2022)

The requirement of IRE1 and XBP1 in resolving physiological stress during Drosophila development
por: Huang, Huai-Wei, et al.
Publicado: (2017)

Pharmacologic IRE1/XBP1s Activation Confers Targeted ER Proteostasis Reprogramming
por: Grandjean, Julia M.D., et al.
Publicado: (2020)

The Role of BiP and the IRE1α–XBP1 Axis in Rhabdomyosarcoma Pathology
por: Aghaei, Mahmoud, et al.
Publicado: (2021)

Pharmacologic IRE1/XBP1s activation promotes systemic adaptive remodeling in obesity
por: Madhavan, Aparajita, et al.
Publicado: (2022)

Ebola Virus Activates IRE1α-Dependent XBP1u Splicing
por: Rohde, Cornelius, et al.
Publicado: (2022)

Iron affects Ire1 clustering propensity and the amplitude of endoplasmic reticulum stress signaling
por: Cohen, Nir, et al.
Publicado: (2017)

XBP1: a link between the unfolded protein response, lipid biosynthesis, and biogenesis of the endoplasmic reticulum
por: Sriburi, Rungtawan, et al.
Publicado: (2004)

Endoplasmic reticulum stress/XBP1 promotes airway mucin secretion under the influence of neutrophil elastase
por: Xu, Xiaoyan, et al.
Publicado: (2021)

Ire1 Has Distinct Catalytic Mechanisms for XBP1/HAC1 Splicing and RIDD
por: Tam, Arvin B., et al.
Publicado: (2014)

l-Glutamine Attenuates Apoptosis Induced by Endoplasmic Reticulum Stress by Activating the IRE1α-XBP1 Axis in IPEC-J2: A Novel Mechanism of l-Glutamine in Promoting Intestinal Health
por: Jiang, Qian, et al.
Publicado: (2017)

Biosensors Show the Pharmacokinetics of S-Ketamine in the Endoplasmic Reticulum
por: Bera, Kallol, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_gpqa2rpsore8d8ofosltlknmkq