Extracorporeal Shock Wave Therapy Promotes Osteogenic Differentiation in a Rabbit Osteoporosis Model

Extracorporeal shock wave therapy (ESWT) has been identified to accelerate bone formation. However, detailed mechanism has not been fully explained. In this study, we found that ESWT promoted osteoblast formation in vitro. Local ESW treatment of femur increased bone formation in vivo. Furthermore, c...

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Autores principales: Li, Baofeng, Wang, Renkai, Huang, Xianyin, Ou, Yongliang, Jia, Zhenyu, Lin, Shanghui, Zhang, Ying, Xia, Hong, Chen, Bei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8027252/
https://www.ncbi.nlm.nih.gov/pubmed/33841330
http://dx.doi.org/10.3389/fendo.2021.627718
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author Li, Baofeng
Wang, Renkai
Huang, Xianyin
Ou, Yongliang
Jia, Zhenyu
Lin, Shanghui
Zhang, Ying
Xia, Hong
Chen, Bei
author_facet Li, Baofeng
Wang, Renkai
Huang, Xianyin
Ou, Yongliang
Jia, Zhenyu
Lin, Shanghui
Zhang, Ying
Xia, Hong
Chen, Bei
author_sort Li, Baofeng
collection PubMed
description Extracorporeal shock wave therapy (ESWT) has been identified to accelerate bone formation. However, detailed mechanism has not been fully explained. In this study, we found that ESWT promoted osteoblast formation in vitro. Local ESW treatment of femur increased bone formation in vivo. Furthermore, changing the density or frequency of energy, there was no statistical difference in osteogenic differentiation. Therapeutically, local ESW therapy relieved bone loss and increased the number of bone trabecular in a rabbit osteoporosis model and promoted endogenous levels of SMAD2 protein expression. Thus, ESWT may be a potential therapy by promoting osteoblast maturation through TGF-β/SMAD2 pathway.
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spelling pubmed-80272522021-04-09 Extracorporeal Shock Wave Therapy Promotes Osteogenic Differentiation in a Rabbit Osteoporosis Model Li, Baofeng Wang, Renkai Huang, Xianyin Ou, Yongliang Jia, Zhenyu Lin, Shanghui Zhang, Ying Xia, Hong Chen, Bei Front Endocrinol (Lausanne) Endocrinology Extracorporeal shock wave therapy (ESWT) has been identified to accelerate bone formation. However, detailed mechanism has not been fully explained. In this study, we found that ESWT promoted osteoblast formation in vitro. Local ESW treatment of femur increased bone formation in vivo. Furthermore, changing the density or frequency of energy, there was no statistical difference in osteogenic differentiation. Therapeutically, local ESW therapy relieved bone loss and increased the number of bone trabecular in a rabbit osteoporosis model and promoted endogenous levels of SMAD2 protein expression. Thus, ESWT may be a potential therapy by promoting osteoblast maturation through TGF-β/SMAD2 pathway. Frontiers Media S.A. 2021-03-25 /pmc/articles/PMC8027252/ /pubmed/33841330 http://dx.doi.org/10.3389/fendo.2021.627718 Text en Copyright © 2021 Li, Wang, Huang, Ou, Jia, Lin, Zhang, Xia and Chen https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Li, Baofeng
Wang, Renkai
Huang, Xianyin
Ou, Yongliang
Jia, Zhenyu
Lin, Shanghui
Zhang, Ying
Xia, Hong
Chen, Bei
Extracorporeal Shock Wave Therapy Promotes Osteogenic Differentiation in a Rabbit Osteoporosis Model
title Extracorporeal Shock Wave Therapy Promotes Osteogenic Differentiation in a Rabbit Osteoporosis Model
title_full Extracorporeal Shock Wave Therapy Promotes Osteogenic Differentiation in a Rabbit Osteoporosis Model
title_fullStr Extracorporeal Shock Wave Therapy Promotes Osteogenic Differentiation in a Rabbit Osteoporosis Model
title_full_unstemmed Extracorporeal Shock Wave Therapy Promotes Osteogenic Differentiation in a Rabbit Osteoporosis Model
title_short Extracorporeal Shock Wave Therapy Promotes Osteogenic Differentiation in a Rabbit Osteoporosis Model
title_sort extracorporeal shock wave therapy promotes osteogenic differentiation in a rabbit osteoporosis model
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8027252/
https://www.ncbi.nlm.nih.gov/pubmed/33841330
http://dx.doi.org/10.3389/fendo.2021.627718
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