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Is γ-secretase a beneficial inactivating enzyme of the toxic APP C-terminal fragment C99?

Genetic, biochemical, and anatomical grounds led to the proposal of the amyloid cascade hypothesis centered on the accumulation of amyloid beta peptides (Aβ) to explain Alzheimer's disease (AD) etiology. In this context, a bulk of efforts have aimed at developing therapeutic strategies seeking...

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Detalles Bibliográficos
Autores principales:	Checler, Frédéric, Afram, Elissa, Pardossi-Piquard, Raphaëlle, Lauritzen, Inger
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2021
Materias:	JBC Reviews
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8027268/ https://www.ncbi.nlm.nih.gov/pubmed/33662398 http://dx.doi.org/10.1016/j.jbc.2021.100489

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