A genome-wide copper-sensitized screen identifies novel regulators of mitochondrial cytochrome c oxidase activity

Copper is essential for the activity and stability of cytochrome c oxidase (CcO), the terminal enzyme of the mitochondrial respiratory chain. Loss-of-function mutations in genes required for copper transport to CcO result in fatal human disorders. Despite the fundamental importance of copper in mito...

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Detalles Bibliográficos
Autores principales: Garza, Natalie M., Griffin, Aaron T., Zulkifli, Mohammad, Qiu, Chenxi, Kaplan, Craig D., Gohil, Vishal M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8027276/
https://www.ncbi.nlm.nih.gov/pubmed/33662401
http://dx.doi.org/10.1016/j.jbc.2021.100485

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8027276/
https://www.ncbi.nlm.nih.gov/pubmed/33662401
http://dx.doi.org/10.1016/j.jbc.2021.100485

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