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A genome-wide copper-sensitized screen identifies novel regulators of mitochondrial cytochrome c oxidase activity

Copper is essential for the activity and stability of cytochrome c oxidase (CcO), the terminal enzyme of the mitochondrial respiratory chain. Loss-of-function mutations in genes required for copper transport to CcO result in fatal human disorders. Despite the fundamental importance of copper in mito...

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Detalles Bibliográficos
Autores principales:	Garza, Natalie M., Griffin, Aaron T., Zulkifli, Mohammad, Qiu, Chenxi, Kaplan, Craig D., Gohil, Vishal M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8027276/ https://www.ncbi.nlm.nih.gov/pubmed/33662401 http://dx.doi.org/10.1016/j.jbc.2021.100485

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