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National and Subnational Incidence, Mortality, and Years of Life Lost Due to Breast Cancer in Iran: Trends and Age-Period-Cohort Analysis Since 1990

Breast cancer is the most common cancer among women, causing considerable burden and mortality. Demographic and lifestyle transitions in low and low-middle income countries have given rise to its increased incidence. The successful management of cancer relies on evidence-based policies taking into a...

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Autores principales: Ataeinia, Bahar, Saeedi Moghaddam, Sahar, Shabani, Mahsima, Gohari, Kimiya, Sheidaei, Ali, Rezaei, Nazila, Naderimagham, Shohreh, Ghasemi, Erfan, Rouhifard Khalilabad, Mahtab, Roshani, Shahin, Farzi, Yosef, Farzadfar, Farshad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8027299/
https://www.ncbi.nlm.nih.gov/pubmed/33842306
http://dx.doi.org/10.3389/fonc.2021.561376
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author Ataeinia, Bahar
Saeedi Moghaddam, Sahar
Shabani, Mahsima
Gohari, Kimiya
Sheidaei, Ali
Rezaei, Nazila
Naderimagham, Shohreh
Ghasemi, Erfan
Rouhifard Khalilabad, Mahtab
Roshani, Shahin
Farzi, Yosef
Farzadfar, Farshad
author_facet Ataeinia, Bahar
Saeedi Moghaddam, Sahar
Shabani, Mahsima
Gohari, Kimiya
Sheidaei, Ali
Rezaei, Nazila
Naderimagham, Shohreh
Ghasemi, Erfan
Rouhifard Khalilabad, Mahtab
Roshani, Shahin
Farzi, Yosef
Farzadfar, Farshad
author_sort Ataeinia, Bahar
collection PubMed
description Breast cancer is the most common cancer among women, causing considerable burden and mortality. Demographic and lifestyle transitions in low and low-middle income countries have given rise to its increased incidence. The successful management of cancer relies on evidence-based policies taking into account national epidemiologic settings. We aimed to report the national and subnational trends of breast cancer incidence, mortality, years of life lost (YLL) and mortality to incidence ratio (MIR) since 1990. As part of the National and Subnational Burden of Diseases project, we estimated incidence, mortality and YLL of breast cancer by sex, age, province, and year using a two-stage spatio-temporal model, based on the primary dataset of national cancer and death registry. MIR was calculated as a quality of care indicator. Age-period-cohort analysis was used to distinguish the effects of these three collinear factors. A significant threefold increase in age-specific incidence at national and subnational levels along with a twofold extension of provincial disparity was observed. Although mortality has slightly decreased since 2000, a positive mortality annual percent change was detected in patients aged 25–34 years, leading to raised YLLs. A significant declining pattern of MIR and lower provincial MIR disparity was observed. We observed a secular increase of breast cancer incidence. Further evaluation of risk factors and developing national screening policies is recommended. A descending pattern of mortality, YLL and MIR at national and subnational levels reflects improved quality of care, even though mortality among younger age groups should be specifically addressed.
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spelling pubmed-80272992021-04-09 National and Subnational Incidence, Mortality, and Years of Life Lost Due to Breast Cancer in Iran: Trends and Age-Period-Cohort Analysis Since 1990 Ataeinia, Bahar Saeedi Moghaddam, Sahar Shabani, Mahsima Gohari, Kimiya Sheidaei, Ali Rezaei, Nazila Naderimagham, Shohreh Ghasemi, Erfan Rouhifard Khalilabad, Mahtab Roshani, Shahin Farzi, Yosef Farzadfar, Farshad Front Oncol Oncology Breast cancer is the most common cancer among women, causing considerable burden and mortality. Demographic and lifestyle transitions in low and low-middle income countries have given rise to its increased incidence. The successful management of cancer relies on evidence-based policies taking into account national epidemiologic settings. We aimed to report the national and subnational trends of breast cancer incidence, mortality, years of life lost (YLL) and mortality to incidence ratio (MIR) since 1990. As part of the National and Subnational Burden of Diseases project, we estimated incidence, mortality and YLL of breast cancer by sex, age, province, and year using a two-stage spatio-temporal model, based on the primary dataset of national cancer and death registry. MIR was calculated as a quality of care indicator. Age-period-cohort analysis was used to distinguish the effects of these three collinear factors. A significant threefold increase in age-specific incidence at national and subnational levels along with a twofold extension of provincial disparity was observed. Although mortality has slightly decreased since 2000, a positive mortality annual percent change was detected in patients aged 25–34 years, leading to raised YLLs. A significant declining pattern of MIR and lower provincial MIR disparity was observed. We observed a secular increase of breast cancer incidence. Further evaluation of risk factors and developing national screening policies is recommended. A descending pattern of mortality, YLL and MIR at national and subnational levels reflects improved quality of care, even though mortality among younger age groups should be specifically addressed. Frontiers Media S.A. 2021-03-25 /pmc/articles/PMC8027299/ /pubmed/33842306 http://dx.doi.org/10.3389/fonc.2021.561376 Text en Copyright © 2021 Ataeinia, Saeedi Moghaddam, Shabani, Gohari, Sheidaei, Rezaei, Naderimagham, Ghasemi, Rouhifard Khalilabad, Roshani, Farzi and Farzadfar https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Ataeinia, Bahar
Saeedi Moghaddam, Sahar
Shabani, Mahsima
Gohari, Kimiya
Sheidaei, Ali
Rezaei, Nazila
Naderimagham, Shohreh
Ghasemi, Erfan
Rouhifard Khalilabad, Mahtab
Roshani, Shahin
Farzi, Yosef
Farzadfar, Farshad
National and Subnational Incidence, Mortality, and Years of Life Lost Due to Breast Cancer in Iran: Trends and Age-Period-Cohort Analysis Since 1990
title National and Subnational Incidence, Mortality, and Years of Life Lost Due to Breast Cancer in Iran: Trends and Age-Period-Cohort Analysis Since 1990
title_full National and Subnational Incidence, Mortality, and Years of Life Lost Due to Breast Cancer in Iran: Trends and Age-Period-Cohort Analysis Since 1990
title_fullStr National and Subnational Incidence, Mortality, and Years of Life Lost Due to Breast Cancer in Iran: Trends and Age-Period-Cohort Analysis Since 1990
title_full_unstemmed National and Subnational Incidence, Mortality, and Years of Life Lost Due to Breast Cancer in Iran: Trends and Age-Period-Cohort Analysis Since 1990
title_short National and Subnational Incidence, Mortality, and Years of Life Lost Due to Breast Cancer in Iran: Trends and Age-Period-Cohort Analysis Since 1990
title_sort national and subnational incidence, mortality, and years of life lost due to breast cancer in iran: trends and age-period-cohort analysis since 1990
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8027299/
https://www.ncbi.nlm.nih.gov/pubmed/33842306
http://dx.doi.org/10.3389/fonc.2021.561376
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