Cargando…

Complement Overactivation and Consumption Predicts In-Hospital Mortality in SARS-CoV-2 Infection

OBJECTIVES: Uncontrolled thromboinflammation plays an important role in the pathogenesis of coronavirus disease (COVID-19) caused by SARS-CoV-2 virus. Complement was implicated as key contributor to this process, therefore we hypothesized that markers of the complement profile, indicative for the ac...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sinkovits, György, Mező, Blanka, Réti, Marienn, Müller, Veronika, Iványi, Zsolt, Gál, János, Gopcsa, László, Reményi, Péter, Szathmáry, Beáta, Lakatos, Botond, Szlávik, János, Bobek, Ilona, Prohászka, Zita Z., Förhécz, Zsolt, Csuka, Dorottya, Hurler, Lisa, Kajdácsi, Erika, Cervenak, László, Kiszel, Petra, Masszi, Tamás, Vályi-Nagy, István, Prohászka, Zoltán
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8027327/ https://www.ncbi.nlm.nih.gov/pubmed/33841446 http://dx.doi.org/10.3389/fimmu.2021.663187

Ejemplares similares

Associations between the von Willebrand Factor—ADAMTS13 Axis, Complement Activation, and COVID-19 Severity and Mortality
por: Sinkovits, György, et al.
Publicado: (2022)

Complement lectin pathway activation is associated with COVID-19 disease severity, independent of MBL2 genotype subgroups
por: Hurler, Lisa, et al.
Publicado: (2023)

Complement Levels at Admission Reflecting Progression to Severe Acute Kidney Injury (AKI) in Coronavirus Disease 2019 (COVID-19): A Multicenter Prospective Cohort Study
por: Henry, Brandon M., et al.
Publicado: (2022)

Decreased circulating dipeptidyl peptidase-4 enzyme activity is prognostic for severe outcomes in COVID-19 inpatients
por: Nádasdi, Ákos, et al.
Publicado: (2022)

Class switch towards spike protein-specific IgG4 antibodies after SARS-CoV-2 mRNA vaccination depends on prior infection history
por: Kiszel, Petra, et al.
Publicado: (2023)

Extracorporeal Photopheresis as a Possible Therapeutic Approach for Adults with Severe and Critical COVID-19 Non-Responsive to Standard Treatment: A Pilot Investigational Study
por: Szabó, Bálint Gergely, et al.
Publicado: (2023)

Evidence, detailed characterization and clinical context of complement activation in acute multisystem inflammatory syndrome in children
por: Sinkovits, György, et al.
Publicado: (2022)

Use of convalescent plasma therapy in hospitalised adult patients with non-critical COVID-19: a focus on the elderly from Hungary
por: Kiss-Dala, Noemi, et al.
Publicado: (2022)

Elevated Systemic Pentraxin-3 Is Associated With Complement Consumption in the Acute Phase of Thrombotic Microangiopathies
por: Trojnar, Eszter, et al.
Publicado: (2019)

Baricitinib vs tocilizumab treatment for hospitalized adult patients with severe COVID-19 and associated cytokine storm: a prospective, investigational, real-world study
por: Lakatos, Botond, et al.
Publicado: (2022)

Distinction of early complement classical and lectin pathway activation via quantification of C1s/C1-INH and MASP-1/C1-INH complexes using novel ELISAs
por: Hurler, Lisa, et al.
Publicado: (2022)

Concentration and Subclass Distribution of Anti-ADAMTS13 IgG Autoantibodies in Different Stages of Acquired Idiopathic Thrombotic Thrombocytopenic Purpura
por: Sinkovits, György, et al.
Publicado: (2018)

Invasive fungal infections among critically ill adult COVID-19 patients: First experiences from the national centre in Hungary
por: Szabo, Balint Gergely, et al.
Publicado: (2021)

Validation of Early Increase in Complement Activation Marker sC5b-9 as a Predictive Biomarker for the Development of Thrombotic Microangiopathy After Stem Cell Transplantation
por: Mezö, Blanka, et al.
Publicado: (2020)

Relationship of circulating cell-free DNA levels to cell-free fetal DNA levels, clinical characteristics and laboratory parameters in preeclampsia
por: Lazar, Levente, et al.
Publicado: (2009)

Comparison of antibody and T cell responses elicited by BBIBP-CorV (Sinopharm) and BNT162b2 (Pfizer-BioNTech) vaccines against SARS-CoV-2 in healthy adult humans
por: Vályi-Nagy, István, et al.
Publicado: (2021)

Decreased Ficolin-3-mediated Complement Lectin Pathway Activation and Alternative Pathway Amplification During Bacterial Infections in Patients With Type 2 Diabetes Mellitus
por: Barkai, László József, et al.
Publicado: (2019)

559. Efficacy and Tolerability of Integrase Inhibitors: Experiences From a Nationwide Real-Life Cohort
por: Lakatos, Botond, et al.
Publicado: (2018)

Outcomes of high-risk adult outpatients treated with early remdesivir therapy during the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) omicron era: experiences from the national centre of Hungary
por: Gáspár, Zsófia, et al.
Publicado: (2023)

Nucleophosmin1 and isocitrate dehydrogenase 1 and 2 as measurable residual disease markers in acute myeloid leukemia
por: Kövy, Petra, et al.
Publicado: (2021)

Pathways of Neutrophil Granulocyte Activation in Hereditary Angioedema with C1 Inhibitor Deficiency
por: Kajdácsi, Erika, et al.
Publicado: (2021)

MASP-1 Increases Endothelial Permeability
por: Debreczeni, Márta L., et al.
Publicado: (2019)

Decreased adhesion to endothelium leads to elevated neutrophil granulocyte count in hereditary angioedema patients
por: Kajdácsi, Erika, et al.
Publicado: (2023)

Targeted Venetoclax Therapy in t(11;14) Multiple Myeloma: Real World Data From Seven Hungarian Centers
por: Szita, Virág Réka, et al.
Publicado: (2022)

Ventilator-associated pneumonia and the importance of education of ICU nurses on prevention – Preliminary results
por: Mogyoródi, Bence, et al.
Publicado: (2016)

Favipiravir treatment does not influence disease progression among adult patients hospitalized with moderate-to-severe COVID-19: a prospective, sequential cohort study from Hungary
por: Szabo, Balint Gergely, et al.
Publicado: (2021)

Molecular Dambusters: What Is Behind Hyperpermeability in Bradykinin-Mediated Angioedema?
por: Debreczeni, Márta L., et al.
Publicado: (2021)

Birds Reveal their Personality when Singing
por: Garamszegi, László Zsolt, et al.
Publicado: (2008)

Cooperation of Complement MASP-1 with Other Proinflammatory Factors to Enhance the Activation of Endothelial Cells
por: Németh, Zsuzsanna, et al.
Publicado: (2023)

Hemolytic uremic syndrome in the setting of COVID-19 successfully treated with complement inhibition therapy: An instructive case report of a previously healthy toddler and review of literature
por: Matošević, Matija, et al.
Publicado: (2023)

A case report of a child with sepsis induced multiorgan failure and massive complement consumption treated with a short course of Eculizumab: A case of crosstalk between coagulation and complement?
por: Galic, Slobodan, et al.
Publicado: (2019)

Sepsis: From Pathophysiology to Individualized Patient Care
por: László, Ildikó, et al.
Publicado: (2015)

A multilayer and spatial description of the Erasmus mobility network
por: Gadár, László, et al.
Publicado: (2020)

C1-inhibitor/C1-inhibitor antibody complexes in acquired angioedema due to C1-inhibitor deficiency
por: Polai, Zsofia, et al.
Publicado: (2023)

Exploring red cell distribution width as a biomarker for treatment efficacy in home mechanical ventilation
por: Valko, Luca, et al.
Publicado: (2022)

Transcriptome analysis of inflammation-related gene expression in endothelial cells activated by complement MASP-1
por: Schwaner, Endre, et al.
Publicado: (2017)

Multiple Myeloma of the Central Nervous System: 13 Cases and Review of the Literature
por: Varga, Gergely, et al.
Publicado: (2018)

Ceftolozane/tazobactam versus colistin in the treatment of ventilator-associated pneumonia due to extensively drug-resistant Pseudomonas aeruginosa
por: Mogyoródi, Bence, et al.
Publicado: (2022)

Human serum fetuin A/α2HS-glycoprotein level is associated with long-term survival in patients with alcoholic liver cirrhosis, comparison with the Child-Pugh and MELD scores
por: Kalabay, László, et al.
Publicado: (2007)

Hydatid disease of pancreas: A case report
por: Deák, János, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_u8u7r9k3ttegjtq7qlqrq9sav5