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Biophysical and Biochemical Cues of Biomaterials Guide Mesenchymal Stem Cell Behaviors
Mesenchymal stem cells (MSCs) have been widely used in the fields of tissue engineering and regenerative medicine due to their self-renewal capabilities and multipotential differentiation assurance. However, capitalizing on specific factors to precisely guide MSC behaviors is the cornerstone of biom...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8027358/ https://www.ncbi.nlm.nih.gov/pubmed/33842464 http://dx.doi.org/10.3389/fcell.2021.640388 |
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author | Li, Jianjun Liu, Yufan Zhang, Yijie Yao, Bin Enhejirigala, Li, Zhao Song, Wei Wang, Yuzhen Duan, Xianlan Yuan, Xingyu Fu, Xiaobing Huang, Sha |
author_facet | Li, Jianjun Liu, Yufan Zhang, Yijie Yao, Bin Enhejirigala, Li, Zhao Song, Wei Wang, Yuzhen Duan, Xianlan Yuan, Xingyu Fu, Xiaobing Huang, Sha |
author_sort | Li, Jianjun |
collection | PubMed |
description | Mesenchymal stem cells (MSCs) have been widely used in the fields of tissue engineering and regenerative medicine due to their self-renewal capabilities and multipotential differentiation assurance. However, capitalizing on specific factors to precisely guide MSC behaviors is the cornerstone of biomedical applications. Fortunately, several key biophysical and biochemical cues of biomaterials that can synergistically regulate cell behavior have paved the way for the development of cell-instructive biomaterials that serve as delivery vehicles for promoting MSC application prospects. Therefore, the identification of these cues in guiding MSC behavior, including cell migration, proliferation, and differentiation, may be of particular importance for better clinical performance. This review focuses on providing a comprehensive and systematic understanding of biophysical and biochemical cues, as well as the strategic engineering of these signals in current scaffold designs, and we believe that integrating biophysical and biochemical cues in next-generation biomaterials would potentially help functionally regulate MSCs for diverse applications in regenerative medicine and cell therapy in the future. |
format | Online Article Text |
id | pubmed-8027358 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-80273582021-04-09 Biophysical and Biochemical Cues of Biomaterials Guide Mesenchymal Stem Cell Behaviors Li, Jianjun Liu, Yufan Zhang, Yijie Yao, Bin Enhejirigala, Li, Zhao Song, Wei Wang, Yuzhen Duan, Xianlan Yuan, Xingyu Fu, Xiaobing Huang, Sha Front Cell Dev Biol Cell and Developmental Biology Mesenchymal stem cells (MSCs) have been widely used in the fields of tissue engineering and regenerative medicine due to their self-renewal capabilities and multipotential differentiation assurance. However, capitalizing on specific factors to precisely guide MSC behaviors is the cornerstone of biomedical applications. Fortunately, several key biophysical and biochemical cues of biomaterials that can synergistically regulate cell behavior have paved the way for the development of cell-instructive biomaterials that serve as delivery vehicles for promoting MSC application prospects. Therefore, the identification of these cues in guiding MSC behavior, including cell migration, proliferation, and differentiation, may be of particular importance for better clinical performance. This review focuses on providing a comprehensive and systematic understanding of biophysical and biochemical cues, as well as the strategic engineering of these signals in current scaffold designs, and we believe that integrating biophysical and biochemical cues in next-generation biomaterials would potentially help functionally regulate MSCs for diverse applications in regenerative medicine and cell therapy in the future. Frontiers Media S.A. 2021-03-25 /pmc/articles/PMC8027358/ /pubmed/33842464 http://dx.doi.org/10.3389/fcell.2021.640388 Text en Copyright © 2021 Li, Liu, Zhang, Yao, Enhejirigala, Li, Song, Wang, Duan, Yuan, Fu and Huang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cell and Developmental Biology Li, Jianjun Liu, Yufan Zhang, Yijie Yao, Bin Enhejirigala, Li, Zhao Song, Wei Wang, Yuzhen Duan, Xianlan Yuan, Xingyu Fu, Xiaobing Huang, Sha Biophysical and Biochemical Cues of Biomaterials Guide Mesenchymal Stem Cell Behaviors |
title | Biophysical and Biochemical Cues of Biomaterials Guide Mesenchymal Stem Cell Behaviors |
title_full | Biophysical and Biochemical Cues of Biomaterials Guide Mesenchymal Stem Cell Behaviors |
title_fullStr | Biophysical and Biochemical Cues of Biomaterials Guide Mesenchymal Stem Cell Behaviors |
title_full_unstemmed | Biophysical and Biochemical Cues of Biomaterials Guide Mesenchymal Stem Cell Behaviors |
title_short | Biophysical and Biochemical Cues of Biomaterials Guide Mesenchymal Stem Cell Behaviors |
title_sort | biophysical and biochemical cues of biomaterials guide mesenchymal stem cell behaviors |
topic | Cell and Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8027358/ https://www.ncbi.nlm.nih.gov/pubmed/33842464 http://dx.doi.org/10.3389/fcell.2021.640388 |
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