Cargando…

Biophysical and Biochemical Cues of Biomaterials Guide Mesenchymal Stem Cell Behaviors

Mesenchymal stem cells (MSCs) have been widely used in the fields of tissue engineering and regenerative medicine due to their self-renewal capabilities and multipotential differentiation assurance. However, capitalizing on specific factors to precisely guide MSC behaviors is the cornerstone of biom...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Jianjun, Liu, Yufan, Zhang, Yijie, Yao, Bin, Enhejirigala, Li, Zhao, Song, Wei, Wang, Yuzhen, Duan, Xianlan, Yuan, Xingyu, Fu, Xiaobing, Huang, Sha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8027358/
https://www.ncbi.nlm.nih.gov/pubmed/33842464
http://dx.doi.org/10.3389/fcell.2021.640388
_version_ 1783675801931087872
author Li, Jianjun
Liu, Yufan
Zhang, Yijie
Yao, Bin
Enhejirigala,
Li, Zhao
Song, Wei
Wang, Yuzhen
Duan, Xianlan
Yuan, Xingyu
Fu, Xiaobing
Huang, Sha
author_facet Li, Jianjun
Liu, Yufan
Zhang, Yijie
Yao, Bin
Enhejirigala,
Li, Zhao
Song, Wei
Wang, Yuzhen
Duan, Xianlan
Yuan, Xingyu
Fu, Xiaobing
Huang, Sha
author_sort Li, Jianjun
collection PubMed
description Mesenchymal stem cells (MSCs) have been widely used in the fields of tissue engineering and regenerative medicine due to their self-renewal capabilities and multipotential differentiation assurance. However, capitalizing on specific factors to precisely guide MSC behaviors is the cornerstone of biomedical applications. Fortunately, several key biophysical and biochemical cues of biomaterials that can synergistically regulate cell behavior have paved the way for the development of cell-instructive biomaterials that serve as delivery vehicles for promoting MSC application prospects. Therefore, the identification of these cues in guiding MSC behavior, including cell migration, proliferation, and differentiation, may be of particular importance for better clinical performance. This review focuses on providing a comprehensive and systematic understanding of biophysical and biochemical cues, as well as the strategic engineering of these signals in current scaffold designs, and we believe that integrating biophysical and biochemical cues in next-generation biomaterials would potentially help functionally regulate MSCs for diverse applications in regenerative medicine and cell therapy in the future.
format Online
Article
Text
id pubmed-8027358
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-80273582021-04-09 Biophysical and Biochemical Cues of Biomaterials Guide Mesenchymal Stem Cell Behaviors Li, Jianjun Liu, Yufan Zhang, Yijie Yao, Bin Enhejirigala, Li, Zhao Song, Wei Wang, Yuzhen Duan, Xianlan Yuan, Xingyu Fu, Xiaobing Huang, Sha Front Cell Dev Biol Cell and Developmental Biology Mesenchymal stem cells (MSCs) have been widely used in the fields of tissue engineering and regenerative medicine due to their self-renewal capabilities and multipotential differentiation assurance. However, capitalizing on specific factors to precisely guide MSC behaviors is the cornerstone of biomedical applications. Fortunately, several key biophysical and biochemical cues of biomaterials that can synergistically regulate cell behavior have paved the way for the development of cell-instructive biomaterials that serve as delivery vehicles for promoting MSC application prospects. Therefore, the identification of these cues in guiding MSC behavior, including cell migration, proliferation, and differentiation, may be of particular importance for better clinical performance. This review focuses on providing a comprehensive and systematic understanding of biophysical and biochemical cues, as well as the strategic engineering of these signals in current scaffold designs, and we believe that integrating biophysical and biochemical cues in next-generation biomaterials would potentially help functionally regulate MSCs for diverse applications in regenerative medicine and cell therapy in the future. Frontiers Media S.A. 2021-03-25 /pmc/articles/PMC8027358/ /pubmed/33842464 http://dx.doi.org/10.3389/fcell.2021.640388 Text en Copyright © 2021 Li, Liu, Zhang, Yao, Enhejirigala, Li, Song, Wang, Duan, Yuan, Fu and Huang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Li, Jianjun
Liu, Yufan
Zhang, Yijie
Yao, Bin
Enhejirigala,
Li, Zhao
Song, Wei
Wang, Yuzhen
Duan, Xianlan
Yuan, Xingyu
Fu, Xiaobing
Huang, Sha
Biophysical and Biochemical Cues of Biomaterials Guide Mesenchymal Stem Cell Behaviors
title Biophysical and Biochemical Cues of Biomaterials Guide Mesenchymal Stem Cell Behaviors
title_full Biophysical and Biochemical Cues of Biomaterials Guide Mesenchymal Stem Cell Behaviors
title_fullStr Biophysical and Biochemical Cues of Biomaterials Guide Mesenchymal Stem Cell Behaviors
title_full_unstemmed Biophysical and Biochemical Cues of Biomaterials Guide Mesenchymal Stem Cell Behaviors
title_short Biophysical and Biochemical Cues of Biomaterials Guide Mesenchymal Stem Cell Behaviors
title_sort biophysical and biochemical cues of biomaterials guide mesenchymal stem cell behaviors
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8027358/
https://www.ncbi.nlm.nih.gov/pubmed/33842464
http://dx.doi.org/10.3389/fcell.2021.640388
work_keys_str_mv AT lijianjun biophysicalandbiochemicalcuesofbiomaterialsguidemesenchymalstemcellbehaviors
AT liuyufan biophysicalandbiochemicalcuesofbiomaterialsguidemesenchymalstemcellbehaviors
AT zhangyijie biophysicalandbiochemicalcuesofbiomaterialsguidemesenchymalstemcellbehaviors
AT yaobin biophysicalandbiochemicalcuesofbiomaterialsguidemesenchymalstemcellbehaviors
AT enhejirigala biophysicalandbiochemicalcuesofbiomaterialsguidemesenchymalstemcellbehaviors
AT lizhao biophysicalandbiochemicalcuesofbiomaterialsguidemesenchymalstemcellbehaviors
AT songwei biophysicalandbiochemicalcuesofbiomaterialsguidemesenchymalstemcellbehaviors
AT wangyuzhen biophysicalandbiochemicalcuesofbiomaterialsguidemesenchymalstemcellbehaviors
AT duanxianlan biophysicalandbiochemicalcuesofbiomaterialsguidemesenchymalstemcellbehaviors
AT yuanxingyu biophysicalandbiochemicalcuesofbiomaterialsguidemesenchymalstemcellbehaviors
AT fuxiaobing biophysicalandbiochemicalcuesofbiomaterialsguidemesenchymalstemcellbehaviors
AT huangsha biophysicalandbiochemicalcuesofbiomaterialsguidemesenchymalstemcellbehaviors