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Mechanical homeostasis of liver sinusoid is involved in the initiation and termination of liver regeneration

Organogenesis and regeneration are fundamental for developmental progress and are associated with morphogenesis, size control and functional properties for whole-body homeostasis. The liver plays an essential role in maintaining homeostasis of the entire body through various functions, including met...

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Autores principales: Ishikawa, Jun, Takeo, Makoto, Iwadate, Ayako, Koya, Junko, Kihira, Miho, Oshima, Masamitsu, Suzuki, Yuki, Taniguchi, Kazushi, Kobayashi, Ayaka, Tsuji, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8027462/
https://www.ncbi.nlm.nih.gov/pubmed/33828226
http://dx.doi.org/10.1038/s42003-021-01936-2
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author Ishikawa, Jun
Takeo, Makoto
Iwadate, Ayako
Koya, Junko
Kihira, Miho
Oshima, Masamitsu
Suzuki, Yuki
Taniguchi, Kazushi
Kobayashi, Ayaka
Tsuji, Takashi
author_facet Ishikawa, Jun
Takeo, Makoto
Iwadate, Ayako
Koya, Junko
Kihira, Miho
Oshima, Masamitsu
Suzuki, Yuki
Taniguchi, Kazushi
Kobayashi, Ayaka
Tsuji, Takashi
author_sort Ishikawa, Jun
collection PubMed
description Organogenesis and regeneration are fundamental for developmental progress and are associated with morphogenesis, size control and functional properties for whole-body homeostasis. The liver plays an essential role in maintaining homeostasis of the entire body through various functions, including metabolic functions, detoxification, and production of bile, via the three-dimensional spatial arrangement of hepatic lobules and has high regenerative capacity. The regeneration occurs as hypertrophy, which strictly controls the size and lobule structure. In this study, we established a three-dimensional sinusoidal network analysis method and determined valuable parameters after partial hepatectomy by comparison to the static phase of the liver. We found that mechanical homeostasis, which is crucial for organ morphogenesis and functions in various phenomena, plays essential roles in liver regeneration for both initiation and termination of liver regeneration, which is regulated by cytokine networks. Mechanical homeostasis plays critical roles in the initiation and termination of organogenesis, tissue repair and organ regeneration in coordination with cytokine networks.
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spelling pubmed-80274622021-04-21 Mechanical homeostasis of liver sinusoid is involved in the initiation and termination of liver regeneration Ishikawa, Jun Takeo, Makoto Iwadate, Ayako Koya, Junko Kihira, Miho Oshima, Masamitsu Suzuki, Yuki Taniguchi, Kazushi Kobayashi, Ayaka Tsuji, Takashi Commun Biol Article Organogenesis and regeneration are fundamental for developmental progress and are associated with morphogenesis, size control and functional properties for whole-body homeostasis. The liver plays an essential role in maintaining homeostasis of the entire body through various functions, including metabolic functions, detoxification, and production of bile, via the three-dimensional spatial arrangement of hepatic lobules and has high regenerative capacity. The regeneration occurs as hypertrophy, which strictly controls the size and lobule structure. In this study, we established a three-dimensional sinusoidal network analysis method and determined valuable parameters after partial hepatectomy by comparison to the static phase of the liver. We found that mechanical homeostasis, which is crucial for organ morphogenesis and functions in various phenomena, plays essential roles in liver regeneration for both initiation and termination of liver regeneration, which is regulated by cytokine networks. Mechanical homeostasis plays critical roles in the initiation and termination of organogenesis, tissue repair and organ regeneration in coordination with cytokine networks. Nature Publishing Group UK 2021-04-07 /pmc/articles/PMC8027462/ /pubmed/33828226 http://dx.doi.org/10.1038/s42003-021-01936-2 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Ishikawa, Jun
Takeo, Makoto
Iwadate, Ayako
Koya, Junko
Kihira, Miho
Oshima, Masamitsu
Suzuki, Yuki
Taniguchi, Kazushi
Kobayashi, Ayaka
Tsuji, Takashi
Mechanical homeostasis of liver sinusoid is involved in the initiation and termination of liver regeneration
title Mechanical homeostasis of liver sinusoid is involved in the initiation and termination of liver regeneration
title_full Mechanical homeostasis of liver sinusoid is involved in the initiation and termination of liver regeneration
title_fullStr Mechanical homeostasis of liver sinusoid is involved in the initiation and termination of liver regeneration
title_full_unstemmed Mechanical homeostasis of liver sinusoid is involved in the initiation and termination of liver regeneration
title_short Mechanical homeostasis of liver sinusoid is involved in the initiation and termination of liver regeneration
title_sort mechanical homeostasis of liver sinusoid is involved in the initiation and termination of liver regeneration
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8027462/
https://www.ncbi.nlm.nih.gov/pubmed/33828226
http://dx.doi.org/10.1038/s42003-021-01936-2
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