Cargando…

A Giant Borderline Phyllodes Tumor of Breast With Skin Ulceration Leading to Non-Insular Tumorigenic Hypoglycemia: A Case Report and Literature Review

Phyllodes tumor (PT) is a special type of breast tumors, including three types: malignant, borderline, and benign. Most of these tumors form unilateral disease and can rapidly increase in size. The occurrence of axillary lymph node metastasis is rare. Tumor-associated hypoglycemia can be divided int...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhao, Jinlu, Gao, Meizhuo, Ren, Yi, Cao, Shaodong, Wang, He, Ge, Ruisheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8027481/
https://www.ncbi.nlm.nih.gov/pubmed/33841338
http://dx.doi.org/10.3389/fendo.2021.651568
_version_ 1783675818923261952
author Zhao, Jinlu
Gao, Meizhuo
Ren, Yi
Cao, Shaodong
Wang, He
Ge, Ruisheng
author_facet Zhao, Jinlu
Gao, Meizhuo
Ren, Yi
Cao, Shaodong
Wang, He
Ge, Ruisheng
author_sort Zhao, Jinlu
collection PubMed
description Phyllodes tumor (PT) is a special type of breast tumors, including three types: malignant, borderline, and benign. Most of these tumors form unilateral disease and can rapidly increase in size. The occurrence of axillary lymph node metastasis is rare. Tumor-associated hypoglycemia can be divided into non-islet cell tumor and insulinoma. In non-islet cell tumor hypoglycemia (NICTH), a considerable high molecular weight form of insulin like growth factor 2 (IGF-2) is formed, which abnormally binds to insulin receptors in the tissues and causes hypoglycemia. Breast phyllodes tumors with NICTH are rare and first reported in 1983. Surgical resection is the main treatment and hypoglycemia symptoms usually resolve after surgery. Nevertheless, prior to surgery, intravenous glucose infusion is used to maintain blood glucose levels. A female patient presented with a rapidly growing breast mass and was diagnosed with a phyllodes tumor with NICTH at our hospital in August 2020; she was successfully treated through surgical resection. We reviewed the relevant literature to investigate and analyze the relationship between NICTH and phyllodes tumors, as well as optimize its diagnosis and treatment.
format Online
Article
Text
id pubmed-8027481
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-80274812021-04-09 A Giant Borderline Phyllodes Tumor of Breast With Skin Ulceration Leading to Non-Insular Tumorigenic Hypoglycemia: A Case Report and Literature Review Zhao, Jinlu Gao, Meizhuo Ren, Yi Cao, Shaodong Wang, He Ge, Ruisheng Front Endocrinol (Lausanne) Endocrinology Phyllodes tumor (PT) is a special type of breast tumors, including three types: malignant, borderline, and benign. Most of these tumors form unilateral disease and can rapidly increase in size. The occurrence of axillary lymph node metastasis is rare. Tumor-associated hypoglycemia can be divided into non-islet cell tumor and insulinoma. In non-islet cell tumor hypoglycemia (NICTH), a considerable high molecular weight form of insulin like growth factor 2 (IGF-2) is formed, which abnormally binds to insulin receptors in the tissues and causes hypoglycemia. Breast phyllodes tumors with NICTH are rare and first reported in 1983. Surgical resection is the main treatment and hypoglycemia symptoms usually resolve after surgery. Nevertheless, prior to surgery, intravenous glucose infusion is used to maintain blood glucose levels. A female patient presented with a rapidly growing breast mass and was diagnosed with a phyllodes tumor with NICTH at our hospital in August 2020; she was successfully treated through surgical resection. We reviewed the relevant literature to investigate and analyze the relationship between NICTH and phyllodes tumors, as well as optimize its diagnosis and treatment. Frontiers Media S.A. 2021-03-25 /pmc/articles/PMC8027481/ /pubmed/33841338 http://dx.doi.org/10.3389/fendo.2021.651568 Text en Copyright © 2021 Zhao, Gao, Ren, Cao, Wang and Ge https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Zhao, Jinlu
Gao, Meizhuo
Ren, Yi
Cao, Shaodong
Wang, He
Ge, Ruisheng
A Giant Borderline Phyllodes Tumor of Breast With Skin Ulceration Leading to Non-Insular Tumorigenic Hypoglycemia: A Case Report and Literature Review
title A Giant Borderline Phyllodes Tumor of Breast With Skin Ulceration Leading to Non-Insular Tumorigenic Hypoglycemia: A Case Report and Literature Review
title_full A Giant Borderline Phyllodes Tumor of Breast With Skin Ulceration Leading to Non-Insular Tumorigenic Hypoglycemia: A Case Report and Literature Review
title_fullStr A Giant Borderline Phyllodes Tumor of Breast With Skin Ulceration Leading to Non-Insular Tumorigenic Hypoglycemia: A Case Report and Literature Review
title_full_unstemmed A Giant Borderline Phyllodes Tumor of Breast With Skin Ulceration Leading to Non-Insular Tumorigenic Hypoglycemia: A Case Report and Literature Review
title_short A Giant Borderline Phyllodes Tumor of Breast With Skin Ulceration Leading to Non-Insular Tumorigenic Hypoglycemia: A Case Report and Literature Review
title_sort giant borderline phyllodes tumor of breast with skin ulceration leading to non-insular tumorigenic hypoglycemia: a case report and literature review
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8027481/
https://www.ncbi.nlm.nih.gov/pubmed/33841338
http://dx.doi.org/10.3389/fendo.2021.651568
work_keys_str_mv AT zhaojinlu agiantborderlinephyllodestumorofbreastwithskinulcerationleadingtononinsulartumorigenichypoglycemiaacasereportandliteraturereview
AT gaomeizhuo agiantborderlinephyllodestumorofbreastwithskinulcerationleadingtononinsulartumorigenichypoglycemiaacasereportandliteraturereview
AT renyi agiantborderlinephyllodestumorofbreastwithskinulcerationleadingtononinsulartumorigenichypoglycemiaacasereportandliteraturereview
AT caoshaodong agiantborderlinephyllodestumorofbreastwithskinulcerationleadingtononinsulartumorigenichypoglycemiaacasereportandliteraturereview
AT wanghe agiantborderlinephyllodestumorofbreastwithskinulcerationleadingtononinsulartumorigenichypoglycemiaacasereportandliteraturereview
AT geruisheng agiantborderlinephyllodestumorofbreastwithskinulcerationleadingtononinsulartumorigenichypoglycemiaacasereportandliteraturereview
AT zhaojinlu giantborderlinephyllodestumorofbreastwithskinulcerationleadingtononinsulartumorigenichypoglycemiaacasereportandliteraturereview
AT gaomeizhuo giantborderlinephyllodestumorofbreastwithskinulcerationleadingtononinsulartumorigenichypoglycemiaacasereportandliteraturereview
AT renyi giantborderlinephyllodestumorofbreastwithskinulcerationleadingtononinsulartumorigenichypoglycemiaacasereportandliteraturereview
AT caoshaodong giantborderlinephyllodestumorofbreastwithskinulcerationleadingtononinsulartumorigenichypoglycemiaacasereportandliteraturereview
AT wanghe giantborderlinephyllodestumorofbreastwithskinulcerationleadingtononinsulartumorigenichypoglycemiaacasereportandliteraturereview
AT geruisheng giantborderlinephyllodestumorofbreastwithskinulcerationleadingtononinsulartumorigenichypoglycemiaacasereportandliteraturereview