The Role of Autophagy in Skeletal Muscle Diseases
Skeletal muscle is the most abundant type of tissue in human body, being involved in diverse activities and maintaining a finely tuned metabolic balance. Autophagy, characterized by the autophagosome–lysosome system with the involvement of evolutionarily conserved autophagy-related genes, is an impo...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8027491/ https://www.ncbi.nlm.nih.gov/pubmed/33841177 http://dx.doi.org/10.3389/fphys.2021.638983 |
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author | Xia, Qianghua Huang, Xubo Huang, Jieru Zheng, Yongfeng March, Michael E. Li, Jin Wei, Yongjie |
author_facet | Xia, Qianghua Huang, Xubo Huang, Jieru Zheng, Yongfeng March, Michael E. Li, Jin Wei, Yongjie |
author_sort | Xia, Qianghua |
collection | PubMed |
description | Skeletal muscle is the most abundant type of tissue in human body, being involved in diverse activities and maintaining a finely tuned metabolic balance. Autophagy, characterized by the autophagosome–lysosome system with the involvement of evolutionarily conserved autophagy-related genes, is an important catabolic process and plays an essential role in energy generation and consumption, as well as substance turnover processes in skeletal muscles. Autophagy in skeletal muscles is finely tuned under the tight regulation of diverse signaling pathways, and the autophagy pathway has cross-talk with other pathways to form feedback loops under physiological conditions and metabolic stress. Altered autophagy activity characterized by either increased formation of autophagosomes or inhibition of lysosome-autophagosome fusion can lead to pathological cascades, and mutations in autophagy genes and deregulation of autophagy pathways have been identified as one of the major causes for a variety of skeleton muscle disorders. The advancement of multi-omics techniques enables further understanding of the molecular and biochemical mechanisms underlying the role of autophagy in skeletal muscle disorders, which may yield novel therapeutic targets for these disorders. |
format | Online Article Text |
id | pubmed-8027491 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-80274912021-04-09 The Role of Autophagy in Skeletal Muscle Diseases Xia, Qianghua Huang, Xubo Huang, Jieru Zheng, Yongfeng March, Michael E. Li, Jin Wei, Yongjie Front Physiol Physiology Skeletal muscle is the most abundant type of tissue in human body, being involved in diverse activities and maintaining a finely tuned metabolic balance. Autophagy, characterized by the autophagosome–lysosome system with the involvement of evolutionarily conserved autophagy-related genes, is an important catabolic process and plays an essential role in energy generation and consumption, as well as substance turnover processes in skeletal muscles. Autophagy in skeletal muscles is finely tuned under the tight regulation of diverse signaling pathways, and the autophagy pathway has cross-talk with other pathways to form feedback loops under physiological conditions and metabolic stress. Altered autophagy activity characterized by either increased formation of autophagosomes or inhibition of lysosome-autophagosome fusion can lead to pathological cascades, and mutations in autophagy genes and deregulation of autophagy pathways have been identified as one of the major causes for a variety of skeleton muscle disorders. The advancement of multi-omics techniques enables further understanding of the molecular and biochemical mechanisms underlying the role of autophagy in skeletal muscle disorders, which may yield novel therapeutic targets for these disorders. Frontiers Media S.A. 2021-03-25 /pmc/articles/PMC8027491/ /pubmed/33841177 http://dx.doi.org/10.3389/fphys.2021.638983 Text en Copyright © 2021 Xia, Huang, Huang, Zheng, March, Li and Wei. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Physiology Xia, Qianghua Huang, Xubo Huang, Jieru Zheng, Yongfeng March, Michael E. Li, Jin Wei, Yongjie The Role of Autophagy in Skeletal Muscle Diseases |
title | The Role of Autophagy in Skeletal Muscle Diseases |
title_full | The Role of Autophagy in Skeletal Muscle Diseases |
title_fullStr | The Role of Autophagy in Skeletal Muscle Diseases |
title_full_unstemmed | The Role of Autophagy in Skeletal Muscle Diseases |
title_short | The Role of Autophagy in Skeletal Muscle Diseases |
title_sort | role of autophagy in skeletal muscle diseases |
topic | Physiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8027491/ https://www.ncbi.nlm.nih.gov/pubmed/33841177 http://dx.doi.org/10.3389/fphys.2021.638983 |
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