Telomeric Double Strand Breaks in G1 Human Cells Facilitate Formation of 5′ C-Rich Overhangs and Recruitment of TERRA

Telomeres, repetitive nucleoprotein complexes that protect chromosomal termini and prevent them from activating inappropriate DNA damage responses (DDRs), shorten with cell division and thus with aging. Here, we characterized the human cellular response to targeted telomeric double-strand breaks (DS...

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Detalles Bibliográficos
Autores principales: Nelson, Christopher B., Alturki, Taghreed M., Luxton, Jared J., Taylor, Lynn E., Maranon, David G., Muraki, Keiko, Murnane, John P., Bailey, Susan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8027502/
https://www.ncbi.nlm.nih.gov/pubmed/33841503
http://dx.doi.org/10.3389/fgene.2021.644803

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8027502/
https://www.ncbi.nlm.nih.gov/pubmed/33841503
http://dx.doi.org/10.3389/fgene.2021.644803

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