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SARS-CoV-2 re-infection: development of an epidemiological definition from India
The current investigation was conducted with the objective to develop an epidemiological case definition of possible severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) re-infection and assess its magnitude in India. The epidemiological case definition for SARS-CoV-2 re-infection was develo...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cambridge University Press
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8027559/ https://www.ncbi.nlm.nih.gov/pubmed/33766185 http://dx.doi.org/10.1017/S0950268821000662 |
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author | Mukherjee, Aparna Anand, Tanu Agarwal, Anup Singh, Harpreet Chatterjee, Pranab Narayan, Jitendra Rana, Salaj Gupta, Nivedita Bhargava, Balram Panda, Samiran |
author_facet | Mukherjee, Aparna Anand, Tanu Agarwal, Anup Singh, Harpreet Chatterjee, Pranab Narayan, Jitendra Rana, Salaj Gupta, Nivedita Bhargava, Balram Panda, Samiran |
author_sort | Mukherjee, Aparna |
collection | PubMed |
description | The current investigation was conducted with the objective to develop an epidemiological case definition of possible severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) re-infection and assess its magnitude in India. The epidemiological case definition for SARS-CoV-2 re-infection was developed from literature review of data on viral kinetics. For achieving second objective, the individuals who satisfied the developed case definition for SARS-CoV-2 re-infection were contacted telephonically. Taking available evidence into consideration, re-infection with SARS-CoV-2 in our study was defined as any individual who tested positive for SARS-CoV-2 on two separate occasions by either molecular tests or rapid antigen test at an interval of at least 102 days with one negative molecular test in between. In this archive based, telephonic survey, 58 out of 1300 individuals (4.5%) fulfilled the above-mentioned definition; 38 individuals could be contacted with healthcare workers (HCWs) accounting for 31.6% of the cases. A large proportion of participants was asymptomatic and had higher Ct value during the first episode. While SARS-CoV-2 re-infection is still a rare phenomenon, there is a need for epidemiological definition of re-infection for establishing surveillance systems and this study contributes to such a goal. Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) re-infection is an emerging concern and there is a need to define it. Therefore, working epidemiological case definition for re-infection was developed and its magnitude was explored via archive-based, telephonic survey. Re-infection with SARS-CoV-2 was defined as two positive tests at an interval of at least 102 days with one interim negative test. Thirty-eight of the 58 eligible patients could be contacted with 12 (31.6%) being HCWs. Majority of the participants were asymptomatic and had higher Ct value during their first episode. To conclude, a working epidemiological case definition of SARS-CoV-2 re-infection is important to strengthen surveillance. The present investigation contributes to this goal and records reinfection in 4.5% of SARS-CoV-2 infected individuals in India. |
format | Online Article Text |
id | pubmed-8027559 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Cambridge University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-80275592021-04-08 SARS-CoV-2 re-infection: development of an epidemiological definition from India Mukherjee, Aparna Anand, Tanu Agarwal, Anup Singh, Harpreet Chatterjee, Pranab Narayan, Jitendra Rana, Salaj Gupta, Nivedita Bhargava, Balram Panda, Samiran Epidemiol Infect From the Field The current investigation was conducted with the objective to develop an epidemiological case definition of possible severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) re-infection and assess its magnitude in India. The epidemiological case definition for SARS-CoV-2 re-infection was developed from literature review of data on viral kinetics. For achieving second objective, the individuals who satisfied the developed case definition for SARS-CoV-2 re-infection were contacted telephonically. Taking available evidence into consideration, re-infection with SARS-CoV-2 in our study was defined as any individual who tested positive for SARS-CoV-2 on two separate occasions by either molecular tests or rapid antigen test at an interval of at least 102 days with one negative molecular test in between. In this archive based, telephonic survey, 58 out of 1300 individuals (4.5%) fulfilled the above-mentioned definition; 38 individuals could be contacted with healthcare workers (HCWs) accounting for 31.6% of the cases. A large proportion of participants was asymptomatic and had higher Ct value during the first episode. While SARS-CoV-2 re-infection is still a rare phenomenon, there is a need for epidemiological definition of re-infection for establishing surveillance systems and this study contributes to such a goal. Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) re-infection is an emerging concern and there is a need to define it. Therefore, working epidemiological case definition for re-infection was developed and its magnitude was explored via archive-based, telephonic survey. Re-infection with SARS-CoV-2 was defined as two positive tests at an interval of at least 102 days with one interim negative test. Thirty-eight of the 58 eligible patients could be contacted with 12 (31.6%) being HCWs. Majority of the participants were asymptomatic and had higher Ct value during their first episode. To conclude, a working epidemiological case definition of SARS-CoV-2 re-infection is important to strengthen surveillance. The present investigation contributes to this goal and records reinfection in 4.5% of SARS-CoV-2 infected individuals in India. Cambridge University Press 2021-03-26 /pmc/articles/PMC8027559/ /pubmed/33766185 http://dx.doi.org/10.1017/S0950268821000662 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | From the Field Mukherjee, Aparna Anand, Tanu Agarwal, Anup Singh, Harpreet Chatterjee, Pranab Narayan, Jitendra Rana, Salaj Gupta, Nivedita Bhargava, Balram Panda, Samiran SARS-CoV-2 re-infection: development of an epidemiological definition from India |
title | SARS-CoV-2 re-infection: development of an epidemiological definition from India |
title_full | SARS-CoV-2 re-infection: development of an epidemiological definition from India |
title_fullStr | SARS-CoV-2 re-infection: development of an epidemiological definition from India |
title_full_unstemmed | SARS-CoV-2 re-infection: development of an epidemiological definition from India |
title_short | SARS-CoV-2 re-infection: development of an epidemiological definition from India |
title_sort | sars-cov-2 re-infection: development of an epidemiological definition from india |
topic | From the Field |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8027559/ https://www.ncbi.nlm.nih.gov/pubmed/33766185 http://dx.doi.org/10.1017/S0950268821000662 |
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