Macrophages bind LDL using heparan sulfate and the perlecan protein core

The retention of low-density lipoprotein (LDL) is a key process in the pathogenesis of atherosclerosis and largely mediated via smooth-muscle cell-derived extracellular proteoglycans including the glycosaminoglycan chains. Macrophages can also internalize lipids via complexes with proteoglycans. How...

Descripción completa

Detalles Bibliográficos
Autores principales: Ng, Chun-yi, Whitelock, John M., Williams, Helen, Kim, Ha Na, Medbury, Heather J., Lord, Megan S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8027565/
https://www.ncbi.nlm.nih.gov/pubmed/33684447
http://dx.doi.org/10.1016/j.jbc.2021.100520

Ejemplares similares

Ejemplares similares