Promoter usage regulating the surface density of CAR molecules may modulate the kinetics of CAR-T cells in vivo

Although chimeric antigen receptor T (CAR-T) cell therapy achieves high remission rates, challenges (e.g., toxicity management and relapse prevention) remain. The major risks are cytokine release syndrome and related neurological toxicity. The influence of the CAR surface density on the efficacy/saf...

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Detalles Bibliográficos
Autores principales: Ho, Jin-Yuan, Wang, Lin, Liu, Ying, Ba, Min, Yang, Junfang, Zhang, Xian, Chen, Dandan, Lu, Peihua, Li, Jianqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8027690/
https://www.ncbi.nlm.nih.gov/pubmed/33869653
http://dx.doi.org/10.1016/j.omtm.2021.03.007

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