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Dexmedetomidine ameliorates endotoxin-induced acute lung injury in vivo and in vitro by preserving mitochondrial dynamic equilibrium through the HIF-1a/HO-1 signaling pathway

Increasing lines of evidence identified that dexmedetomidine (DEX) exerted protective effects against sepsis-stimulated acute lung injury via anti-inflammation, anti-oxidation and anti-apoptosis. However, the mechanisms remain unclear. Herein, we investigated whether DEX afforded lung protection by...

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Detalles Bibliográficos
Autores principales:	Shi, Jia, Yu, Tianxi, Song, Kai, Du, Shihan, He, Simeng, Hu, Xinxin, Li, Xiangyun, Li, Haibo, Dong, Shuan, Zhang, Yuan, Xie, Zilei, Li, Cui, Yu, Jianbo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8027777/ https://www.ncbi.nlm.nih.gov/pubmed/33774474 http://dx.doi.org/10.1016/j.redox.2021.101954

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