Targeting TOPK sensitises tumour cells to radiation-induced damage by enhancing replication stress

T-LAK-originated protein kinase (TOPK) overexpression is a feature of multiple cancers, yet is absent from most phenotypically normal tissues. As such, TOPK expression profiling and the development of TOPK-targeting pharmaceutical agents have raised hopes for its future potential in the development...

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Detalles Bibliográficos
Autores principales: Herbert, Katharine J., Puliyadi, Rathi, Prevo, Remko, Rodriguez-Berriguete, Gonzalo, Ryan, Anderson, Ramadan, Kristijan, Higgins, Geoff S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8027845/
https://www.ncbi.nlm.nih.gov/pubmed/33168956
http://dx.doi.org/10.1038/s41418-020-00655-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8027845/
https://www.ncbi.nlm.nih.gov/pubmed/33168956
http://dx.doi.org/10.1038/s41418-020-00655-1

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