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Targeting TOPK sensitises tumour cells to radiation-induced damage by enhancing replication stress
T-LAK-originated protein kinase (TOPK) overexpression is a feature of multiple cancers, yet is absent from most phenotypically normal tissues. As such, TOPK expression profiling and the development of TOPK-targeting pharmaceutical agents have raised hopes for its future potential in the development...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8027845/ https://www.ncbi.nlm.nih.gov/pubmed/33168956 http://dx.doi.org/10.1038/s41418-020-00655-1 |