Silencing PTEN in the fallopian tube promotes enrichment of cancer stem cell-like function through loss of PAX2

High-grade serous ovarian cancer (HGSOC) is the most lethal gynecological malignancy that is primarily detected at the metastatic stage. Most HGSOC originates from the fallopian tube epithelium (FTE) and metastasizes to the ovary before invading the peritoneum; therefore, it is crucial to study dise...

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Detalles Bibliográficos
Autores principales: Russo, Angela, Colina, Jose A., Moy, Junlone, Baligod, Seth, Czarnecki, Austin A., Varughese, Peter, Lantvit, Daniel D., Dean, Matthew J., Burdette, Joanna E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8027874/
https://www.ncbi.nlm.nih.gov/pubmed/33828085
http://dx.doi.org/10.1038/s41419-021-03663-2

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