The aryl hydrocarbon receptor and the gut–brain axis

The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor initially identified as the receptor for dioxin. Almost half a century after its discovery, AHR is now recognized as a receptor for multiple physiological ligands, with important roles in health and disease. In this revie...

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Autores principales: Barroso, Andreia, Mahler, João Vitor, Fonseca-Castro, Pedro Henrique, Quintana, Francisco J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8027889/
https://www.ncbi.nlm.nih.gov/pubmed/33408340
http://dx.doi.org/10.1038/s41423-020-00585-5
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author Barroso, Andreia
Mahler, João Vitor
Fonseca-Castro, Pedro Henrique
Quintana, Francisco J.
author_facet Barroso, Andreia
Mahler, João Vitor
Fonseca-Castro, Pedro Henrique
Quintana, Francisco J.
author_sort Barroso, Andreia
collection PubMed
description The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor initially identified as the receptor for dioxin. Almost half a century after its discovery, AHR is now recognized as a receptor for multiple physiological ligands, with important roles in health and disease. In this review, we discuss the role of AHR in the gut–brain axis and its potential value as a therapeutic target for immune-mediated diseases.
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spelling pubmed-80278892021-04-21 The aryl hydrocarbon receptor and the gut–brain axis Barroso, Andreia Mahler, João Vitor Fonseca-Castro, Pedro Henrique Quintana, Francisco J. Cell Mol Immunol Review Article The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor initially identified as the receptor for dioxin. Almost half a century after its discovery, AHR is now recognized as a receptor for multiple physiological ligands, with important roles in health and disease. In this review, we discuss the role of AHR in the gut–brain axis and its potential value as a therapeutic target for immune-mediated diseases. Nature Publishing Group UK 2021-01-06 2021-02 /pmc/articles/PMC8027889/ /pubmed/33408340 http://dx.doi.org/10.1038/s41423-020-00585-5 Text en © The Author(s), under exclusive licence to CSI and USTC 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Review Article
Barroso, Andreia
Mahler, João Vitor
Fonseca-Castro, Pedro Henrique
Quintana, Francisco J.
The aryl hydrocarbon receptor and the gut–brain axis
title The aryl hydrocarbon receptor and the gut–brain axis
title_full The aryl hydrocarbon receptor and the gut–brain axis
title_fullStr The aryl hydrocarbon receptor and the gut–brain axis
title_full_unstemmed The aryl hydrocarbon receptor and the gut–brain axis
title_short The aryl hydrocarbon receptor and the gut–brain axis
title_sort aryl hydrocarbon receptor and the gut–brain axis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8027889/
https://www.ncbi.nlm.nih.gov/pubmed/33408340
http://dx.doi.org/10.1038/s41423-020-00585-5
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