Total Synthesis of 6-Hydroxymetatacarboline-d Discovered from Mycena metata via the Pictet–Spengler Reaction Followed by the Horner–Wadsworth–Emmons Reaction

[Image: see text] Total synthesis of a new β-carboline alkaloid, 6-hydroxymetatacarboline-d, which was isolated from fruiting bodies of Mycena metata was accomplished in 14 steps. The synthetic strategy features the Pictet–Spengler reaction to construct the tricyclic core followed by amide coupling...

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Autores principales: Kumar, Deepak, Vaya, Dipti, Chundawat, Tejpal Singh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8028005/
https://www.ncbi.nlm.nih.gov/pubmed/33842763
http://dx.doi.org/10.1021/acsomega.0c06202
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author Kumar, Deepak
Vaya, Dipti
Chundawat, Tejpal Singh
author_facet Kumar, Deepak
Vaya, Dipti
Chundawat, Tejpal Singh
author_sort Kumar, Deepak
collection PubMed
description [Image: see text] Total synthesis of a new β-carboline alkaloid, 6-hydroxymetatacarboline-d, which was isolated from fruiting bodies of Mycena metata was accomplished in 14 steps. The synthetic strategy features the Pictet–Spengler reaction to construct the tricyclic core followed by amide coupling and the Horner–Wadsworth–Emmons reaction.
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spelling pubmed-80280052021-04-09 Total Synthesis of 6-Hydroxymetatacarboline-d Discovered from Mycena metata via the Pictet–Spengler Reaction Followed by the Horner–Wadsworth–Emmons Reaction Kumar, Deepak Vaya, Dipti Chundawat, Tejpal Singh ACS Omega [Image: see text] Total synthesis of a new β-carboline alkaloid, 6-hydroxymetatacarboline-d, which was isolated from fruiting bodies of Mycena metata was accomplished in 14 steps. The synthetic strategy features the Pictet–Spengler reaction to construct the tricyclic core followed by amide coupling and the Horner–Wadsworth–Emmons reaction. American Chemical Society 2021-03-27 /pmc/articles/PMC8028005/ /pubmed/33842763 http://dx.doi.org/10.1021/acsomega.0c06202 Text en © 2021 The Authors. Published by American Chemical Society Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Kumar, Deepak
Vaya, Dipti
Chundawat, Tejpal Singh
Total Synthesis of 6-Hydroxymetatacarboline-d Discovered from Mycena metata via the Pictet–Spengler Reaction Followed by the Horner–Wadsworth–Emmons Reaction
title Total Synthesis of 6-Hydroxymetatacarboline-d Discovered from Mycena metata via the Pictet–Spengler Reaction Followed by the Horner–Wadsworth–Emmons Reaction
title_full Total Synthesis of 6-Hydroxymetatacarboline-d Discovered from Mycena metata via the Pictet–Spengler Reaction Followed by the Horner–Wadsworth–Emmons Reaction
title_fullStr Total Synthesis of 6-Hydroxymetatacarboline-d Discovered from Mycena metata via the Pictet–Spengler Reaction Followed by the Horner–Wadsworth–Emmons Reaction
title_full_unstemmed Total Synthesis of 6-Hydroxymetatacarboline-d Discovered from Mycena metata via the Pictet–Spengler Reaction Followed by the Horner–Wadsworth–Emmons Reaction
title_short Total Synthesis of 6-Hydroxymetatacarboline-d Discovered from Mycena metata via the Pictet–Spengler Reaction Followed by the Horner–Wadsworth–Emmons Reaction
title_sort total synthesis of 6-hydroxymetatacarboline-d discovered from mycena metata via the pictet–spengler reaction followed by the horner–wadsworth–emmons reaction
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8028005/
https://www.ncbi.nlm.nih.gov/pubmed/33842763
http://dx.doi.org/10.1021/acsomega.0c06202
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