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Synchronous intrathyroidal parathyroid carcinoma and thyroid carcinoma: case report and review of the literature
BACKGROUND: Parathyroid carcinoma is a rare endocrine malignancy, rarer when synchronous with a non medullary well differentiated thyroid carcinoma. Parathyroid carcinoma accounts of 0.005% of all malignant tumors and it is responsible for less than 1% of primary hyperparathyroidism. The intrathyroi...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8028146/ https://www.ncbi.nlm.nih.gov/pubmed/33827539 http://dx.doi.org/10.1186/s12902-021-00724-7 |
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author | De Falco, Nadia Santangelo, Giuseppe Chirico, Fabrizio Cangiano, Angelo Sommella, Maria Giulia Cosenza, Angelo Ronchi, Andrea Accardo, Marina Pellino, Gianluca Parmeggiani, Domenico Canonico, Silvestro De Falco, Massimo |
author_facet | De Falco, Nadia Santangelo, Giuseppe Chirico, Fabrizio Cangiano, Angelo Sommella, Maria Giulia Cosenza, Angelo Ronchi, Andrea Accardo, Marina Pellino, Gianluca Parmeggiani, Domenico Canonico, Silvestro De Falco, Massimo |
author_sort | De Falco, Nadia |
collection | PubMed |
description | BACKGROUND: Parathyroid carcinoma is a rare endocrine malignancy, rarer when synchronous with a non medullary well differentiated thyroid carcinoma. Parathyroid carcinoma accounts of 0.005% of all malignant tumors and it is responsible for less than 1% of primary hyperparathyroidism. The intrathyroidal localization of a parathyroid gland is not frequent with a reported prevalence of 0.2%. Carcinoma of parathyroids with intrathyroidal localization represents an even rarer finding, reported in only 16 cases described in literature. The rare constellation of synchronous parathyroid and thyroid carcinomas has prompted us to report our experience and perform literature review. CASE PRESENTATION: We herein report a case of a 63-years-old man with multinodular goiter and biochemical diagnosis of hyperparathyroidism. Total thyroidectomy with radio-guide technique using gamma probe after intraoperative sesta-MIBI administration and intraoperative PTH level was performed. The high radiation levels in the posterior thyroid lobe discovered an intrathyroidal parathyroid. Microscopic examination revealed a parathyroid main cell carcinoma at the posterior thyroidal left basal lobe, a classic papillary carcinoma at the same lobe and follicular variant of papillary carcinoma at the thyroidal right lobe. To the best of our knowledge, this is the first case documenting a synchronous multicentric non medullary thyroid carcinomas and intrathyroidal parathyroid carcinoma. CONCLUSIONS: Our experience was reported and literature review underlining challenging difficulties in diagnostic workup and surgical management was carried out. |
format | Online Article Text |
id | pubmed-8028146 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-80281462021-04-08 Synchronous intrathyroidal parathyroid carcinoma and thyroid carcinoma: case report and review of the literature De Falco, Nadia Santangelo, Giuseppe Chirico, Fabrizio Cangiano, Angelo Sommella, Maria Giulia Cosenza, Angelo Ronchi, Andrea Accardo, Marina Pellino, Gianluca Parmeggiani, Domenico Canonico, Silvestro De Falco, Massimo BMC Endocr Disord Case Report BACKGROUND: Parathyroid carcinoma is a rare endocrine malignancy, rarer when synchronous with a non medullary well differentiated thyroid carcinoma. Parathyroid carcinoma accounts of 0.005% of all malignant tumors and it is responsible for less than 1% of primary hyperparathyroidism. The intrathyroidal localization of a parathyroid gland is not frequent with a reported prevalence of 0.2%. Carcinoma of parathyroids with intrathyroidal localization represents an even rarer finding, reported in only 16 cases described in literature. The rare constellation of synchronous parathyroid and thyroid carcinomas has prompted us to report our experience and perform literature review. CASE PRESENTATION: We herein report a case of a 63-years-old man with multinodular goiter and biochemical diagnosis of hyperparathyroidism. Total thyroidectomy with radio-guide technique using gamma probe after intraoperative sesta-MIBI administration and intraoperative PTH level was performed. The high radiation levels in the posterior thyroid lobe discovered an intrathyroidal parathyroid. Microscopic examination revealed a parathyroid main cell carcinoma at the posterior thyroidal left basal lobe, a classic papillary carcinoma at the same lobe and follicular variant of papillary carcinoma at the thyroidal right lobe. To the best of our knowledge, this is the first case documenting a synchronous multicentric non medullary thyroid carcinomas and intrathyroidal parathyroid carcinoma. CONCLUSIONS: Our experience was reported and literature review underlining challenging difficulties in diagnostic workup and surgical management was carried out. BioMed Central 2021-04-07 /pmc/articles/PMC8028146/ /pubmed/33827539 http://dx.doi.org/10.1186/s12902-021-00724-7 Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Case Report De Falco, Nadia Santangelo, Giuseppe Chirico, Fabrizio Cangiano, Angelo Sommella, Maria Giulia Cosenza, Angelo Ronchi, Andrea Accardo, Marina Pellino, Gianluca Parmeggiani, Domenico Canonico, Silvestro De Falco, Massimo Synchronous intrathyroidal parathyroid carcinoma and thyroid carcinoma: case report and review of the literature |
title | Synchronous intrathyroidal parathyroid carcinoma and thyroid carcinoma: case report and review of the literature |
title_full | Synchronous intrathyroidal parathyroid carcinoma and thyroid carcinoma: case report and review of the literature |
title_fullStr | Synchronous intrathyroidal parathyroid carcinoma and thyroid carcinoma: case report and review of the literature |
title_full_unstemmed | Synchronous intrathyroidal parathyroid carcinoma and thyroid carcinoma: case report and review of the literature |
title_short | Synchronous intrathyroidal parathyroid carcinoma and thyroid carcinoma: case report and review of the literature |
title_sort | synchronous intrathyroidal parathyroid carcinoma and thyroid carcinoma: case report and review of the literature |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8028146/ https://www.ncbi.nlm.nih.gov/pubmed/33827539 http://dx.doi.org/10.1186/s12902-021-00724-7 |
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