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Paediatrics: how to manage infantile haemangioma

Infantile haemangiomas (IHs) are relatively common benign vascular tumours found in the paediatric population. They have varying sizes and involve different depths in the skin leading to various colours, shapes and textures. Although considered harmless in most cases, they may lead to life-threateni...

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Detalles Bibliográficos
Autores principales: Kim, Jason HS, Lam, Joseph M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioExcel Publishing Ltd 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8029639/
https://www.ncbi.nlm.nih.gov/pubmed/33889196
http://dx.doi.org/10.7573/dic.2020-12-6
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author Kim, Jason HS
Lam, Joseph M
author_facet Kim, Jason HS
Lam, Joseph M
author_sort Kim, Jason HS
collection PubMed
description Infantile haemangiomas (IHs) are relatively common benign vascular tumours found in the paediatric population. They have varying sizes and involve different depths in the skin leading to various colours, shapes and textures. Although considered harmless in most cases, they may lead to life-threatening complications or cause permanent disfigurations and organ dysfunction. For problematic IHs, the treatment options include oral and topical beta-blockers, systemic corticosteroids, laser treatment, and surgery. In this narrative review, the treatment options for problematic IH are compared and delivered concisely to facilitate the clinical decisions from practitioners, including those in primary care settings. Oral propranolol is currently considered the first-line intervention for problematic IHs. For superficial lesions, there is robust evidence for the use of topical timolol maleate. Systemic corticosteroids are sometimes used in specific situations such as resistance or contraindications to beta-blockers. Surgical excision can be considered in cases requiring urgent intervention such as airway obstruction; this can be done alongside laser therapies for the removal of residual tissue or when reconstructing areas of deformity. The combination of multiple treatment modalities may lead to a more rapid clinical response.
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spelling pubmed-80296392021-04-21 Paediatrics: how to manage infantile haemangioma Kim, Jason HS Lam, Joseph M Drugs Context Review Infantile haemangiomas (IHs) are relatively common benign vascular tumours found in the paediatric population. They have varying sizes and involve different depths in the skin leading to various colours, shapes and textures. Although considered harmless in most cases, they may lead to life-threatening complications or cause permanent disfigurations and organ dysfunction. For problematic IHs, the treatment options include oral and topical beta-blockers, systemic corticosteroids, laser treatment, and surgery. In this narrative review, the treatment options for problematic IH are compared and delivered concisely to facilitate the clinical decisions from practitioners, including those in primary care settings. Oral propranolol is currently considered the first-line intervention for problematic IHs. For superficial lesions, there is robust evidence for the use of topical timolol maleate. Systemic corticosteroids are sometimes used in specific situations such as resistance or contraindications to beta-blockers. Surgical excision can be considered in cases requiring urgent intervention such as airway obstruction; this can be done alongside laser therapies for the removal of residual tissue or when reconstructing areas of deformity. The combination of multiple treatment modalities may lead to a more rapid clinical response. BioExcel Publishing Ltd 2021-04-06 /pmc/articles/PMC8029639/ /pubmed/33889196 http://dx.doi.org/10.7573/dic.2020-12-6 Text en Copyright © 2021 Kim JHS, Lam JM https://creativecommons.org/licenses/by-nc-nd/4.0/Published by Drugs in Context under Creative Commons License Deed CC BY NC ND 4.0 which allows anyone to copy, distribute, and transmit the article provided it is properly attributed in the manner specified below. No commercial use without permission.
spellingShingle Review
Kim, Jason HS
Lam, Joseph M
Paediatrics: how to manage infantile haemangioma
title Paediatrics: how to manage infantile haemangioma
title_full Paediatrics: how to manage infantile haemangioma
title_fullStr Paediatrics: how to manage infantile haemangioma
title_full_unstemmed Paediatrics: how to manage infantile haemangioma
title_short Paediatrics: how to manage infantile haemangioma
title_sort paediatrics: how to manage infantile haemangioma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8029639/
https://www.ncbi.nlm.nih.gov/pubmed/33889196
http://dx.doi.org/10.7573/dic.2020-12-6
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