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Intravenous contrast use and acute kidney injury: a retrospective study of 1,238 inpatients undergoing computed tomography

OBJECTIVE: To determine the incidence of nephropathy induced by intravenous contrast in hospitalized patients undergoing computed tomography (CT). MATERIALS AND METHODS: This was a retrospective cohort study involving 1,238 patients who underwent CT with or without intravenous administration of a co...

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Detalles Bibliográficos
Autores principales: Coser, Thyago A., Leitão, Juliana S. V., Beltrame, Betina M., Selistre, Luciano S., Tasso, Leandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Publicação do Colégio Brasileiro de Radiologia e Diagnóstico por Imagem 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8029938/
https://www.ncbi.nlm.nih.gov/pubmed/33854260
http://dx.doi.org/10.1590/0100-3984.2020.0018
Descripción
Sumario:OBJECTIVE: To determine the incidence of nephropathy induced by intravenous contrast in hospitalized patients undergoing computed tomography (CT). MATERIALS AND METHODS: This was a retrospective cohort study involving 1,238 patients who underwent CT with or without intravenous administration of a contrast agent (iopromide). The primary outcome measure was acute kidney injury (AKI), as defined by the traditional criteria-an absolute or relative increase in serum creatinine (SCr) ≥ 0.5 mg/dL or ≥ 25% over baseline, respectively, at 2-3 days after contrast administration-and the newer, Kidney Disease: Improving Global Outcomes (KDIGO) criteria-an absolute or relative increase in SCr ≥ 0.3 mg/dL or ≥ 50% over baseline, respectively, at 2-7 days after contrast administration. RESULTS: The overall incidence of AKI was 11.52% when the KDIGO criteria were applied. Univariate logistic regression demonstrated a significant association between an absolute post-CT increase in SCr ≥ 0.5 mg/dL and AKI, although that association did not retain significance in the multivariate analysis. Multivariate logistic regression initially found an association between an absolute post-CT increase in SCr ≥ 0.3 mg/dL and advanced age, although that association was not maintained after correction. We found no association between AKI and the risk factors evaluated. CONCLUSION: We identified no criteria for contrast-induced nephropathy after CT; nor did we find AKI to be associated with the classical risk factors.