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Molecular Mechanisms of Endocrine Resistance in Estrogen-Receptor-Positive Breast Cancer

The estrogen receptor is a vital receptor for therapeutic targets in estrogen receptor-positive breast cancer. The main strategy for the treatment of estrogen receptor-positive breast cancers is blocking the estrogen action on estrogen receptors by endocrine therapy but this can be restricted via en...

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Autores principales: Belachew, Esmael Besufikad, Sewasew, Dareskedar Tsehay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8030661/
https://www.ncbi.nlm.nih.gov/pubmed/33841325
http://dx.doi.org/10.3389/fendo.2021.599586
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author Belachew, Esmael Besufikad
Sewasew, Dareskedar Tsehay
author_facet Belachew, Esmael Besufikad
Sewasew, Dareskedar Tsehay
author_sort Belachew, Esmael Besufikad
collection PubMed
description The estrogen receptor is a vital receptor for therapeutic targets in estrogen receptor-positive breast cancer. The main strategy for the treatment of estrogen receptor-positive breast cancers is blocking the estrogen action on estrogen receptors by endocrine therapy but this can be restricted via endocrine resistance. Endocrine resistance occurs due to both de novo and acquired resistance. This review focuses on the mechanisms of the ligand-dependent and ligand-independent pathways and other coregulators, which are responsible for endocrine resistance. It concludes that combinatorial drugs that target different signaling pathways and coregulatory proteins together with endocrine therapy could be a novel therapeutic modality to stop endocrine resistance.
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spelling pubmed-80306612021-04-09 Molecular Mechanisms of Endocrine Resistance in Estrogen-Receptor-Positive Breast Cancer Belachew, Esmael Besufikad Sewasew, Dareskedar Tsehay Front Endocrinol (Lausanne) Endocrinology The estrogen receptor is a vital receptor for therapeutic targets in estrogen receptor-positive breast cancer. The main strategy for the treatment of estrogen receptor-positive breast cancers is blocking the estrogen action on estrogen receptors by endocrine therapy but this can be restricted via endocrine resistance. Endocrine resistance occurs due to both de novo and acquired resistance. This review focuses on the mechanisms of the ligand-dependent and ligand-independent pathways and other coregulators, which are responsible for endocrine resistance. It concludes that combinatorial drugs that target different signaling pathways and coregulatory proteins together with endocrine therapy could be a novel therapeutic modality to stop endocrine resistance. Frontiers Media S.A. 2021-03-25 /pmc/articles/PMC8030661/ /pubmed/33841325 http://dx.doi.org/10.3389/fendo.2021.599586 Text en Copyright © 2021 Belachew and Sewasew https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Belachew, Esmael Besufikad
Sewasew, Dareskedar Tsehay
Molecular Mechanisms of Endocrine Resistance in Estrogen-Receptor-Positive Breast Cancer
title Molecular Mechanisms of Endocrine Resistance in Estrogen-Receptor-Positive Breast Cancer
title_full Molecular Mechanisms of Endocrine Resistance in Estrogen-Receptor-Positive Breast Cancer
title_fullStr Molecular Mechanisms of Endocrine Resistance in Estrogen-Receptor-Positive Breast Cancer
title_full_unstemmed Molecular Mechanisms of Endocrine Resistance in Estrogen-Receptor-Positive Breast Cancer
title_short Molecular Mechanisms of Endocrine Resistance in Estrogen-Receptor-Positive Breast Cancer
title_sort molecular mechanisms of endocrine resistance in estrogen-receptor-positive breast cancer
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8030661/
https://www.ncbi.nlm.nih.gov/pubmed/33841325
http://dx.doi.org/10.3389/fendo.2021.599586
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