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Predictive utility of task-related functional connectivity vs. voxel activation

Functional connectivity, both in resting state and task performance, has steadily increased its share of neuroimaging research effort in the last 1.5 decades. In the current study, we investigated the predictive utility regarding behavioral performance and task information for 240 participants, aged...

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Autores principales: Habeck, Christian, Razlighi, Qolamreza, Stern, Yaakov
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8031148/
https://www.ncbi.nlm.nih.gov/pubmed/33831098
http://dx.doi.org/10.1371/journal.pone.0249947
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author Habeck, Christian
Razlighi, Qolamreza
Stern, Yaakov
author_facet Habeck, Christian
Razlighi, Qolamreza
Stern, Yaakov
author_sort Habeck, Christian
collection PubMed
description Functional connectivity, both in resting state and task performance, has steadily increased its share of neuroimaging research effort in the last 1.5 decades. In the current study, we investigated the predictive utility regarding behavioral performance and task information for 240 participants, aged 20–77, for both voxel activation and functional connectivity in 12 cognitive tasks, belonging to 4 cognitive reference domains (Episodic Memory, Fluid Reasoning, Perceptual Speed, and Vocabulary). We also added a model only comprising brain-structure information not specifically acquired during performance of a cognitive task. We used a simple brain-behavioral prediction technique based on Principal Component Analysis (PCA) and regression and studied the utility of both modalities in quasi out-of-sample predictions, using split-sample simulations (= 5-fold Monte Carlo cross validation) with 1,000 iterations for which a regression model predicting a cognitive outcome was estimated in a training sample, with a subsequent assessment of prediction success in a non-overlapping test sample. The sample assignments were identical for functional connectivity, voxel activation, and brain structure, enabling apples-to-apples comparisons of predictive utility. All 3 models that were investigated included the demographic covariates age, gender, and years of education. A minimal reference model using simple linear regression with just these 3 covariates was included for comparison as well and was evaluated with the same resampling scheme as described above. Results of the comparison between voxel activation and functional connectivity were mixed and showed some dependency on cognitive outcome; however, mean differences in predictive utility between voxel activation and functional connectivity were rather small in terms of within-modality variability or predictive success. More notably, only in the case of Fluid Reasoning did concurrent functional neuroimaging provided compelling about cognitive performance beyond structural brain imaging or the minimal reference model.
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spelling pubmed-80311482021-04-14 Predictive utility of task-related functional connectivity vs. voxel activation Habeck, Christian Razlighi, Qolamreza Stern, Yaakov PLoS One Research Article Functional connectivity, both in resting state and task performance, has steadily increased its share of neuroimaging research effort in the last 1.5 decades. In the current study, we investigated the predictive utility regarding behavioral performance and task information for 240 participants, aged 20–77, for both voxel activation and functional connectivity in 12 cognitive tasks, belonging to 4 cognitive reference domains (Episodic Memory, Fluid Reasoning, Perceptual Speed, and Vocabulary). We also added a model only comprising brain-structure information not specifically acquired during performance of a cognitive task. We used a simple brain-behavioral prediction technique based on Principal Component Analysis (PCA) and regression and studied the utility of both modalities in quasi out-of-sample predictions, using split-sample simulations (= 5-fold Monte Carlo cross validation) with 1,000 iterations for which a regression model predicting a cognitive outcome was estimated in a training sample, with a subsequent assessment of prediction success in a non-overlapping test sample. The sample assignments were identical for functional connectivity, voxel activation, and brain structure, enabling apples-to-apples comparisons of predictive utility. All 3 models that were investigated included the demographic covariates age, gender, and years of education. A minimal reference model using simple linear regression with just these 3 covariates was included for comparison as well and was evaluated with the same resampling scheme as described above. Results of the comparison between voxel activation and functional connectivity were mixed and showed some dependency on cognitive outcome; however, mean differences in predictive utility between voxel activation and functional connectivity were rather small in terms of within-modality variability or predictive success. More notably, only in the case of Fluid Reasoning did concurrent functional neuroimaging provided compelling about cognitive performance beyond structural brain imaging or the minimal reference model. Public Library of Science 2021-04-08 /pmc/articles/PMC8031148/ /pubmed/33831098 http://dx.doi.org/10.1371/journal.pone.0249947 Text en © 2021 Habeck et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Habeck, Christian
Razlighi, Qolamreza
Stern, Yaakov
Predictive utility of task-related functional connectivity vs. voxel activation
title Predictive utility of task-related functional connectivity vs. voxel activation
title_full Predictive utility of task-related functional connectivity vs. voxel activation
title_fullStr Predictive utility of task-related functional connectivity vs. voxel activation
title_full_unstemmed Predictive utility of task-related functional connectivity vs. voxel activation
title_short Predictive utility of task-related functional connectivity vs. voxel activation
title_sort predictive utility of task-related functional connectivity vs. voxel activation
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8031148/
https://www.ncbi.nlm.nih.gov/pubmed/33831098
http://dx.doi.org/10.1371/journal.pone.0249947
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