Cargando…

Polypharmacy among people living with type 2 diabetes mellitus in rural communes in Vietnam

OBJECTIVES: People with diabetes are at high risk of polypharmacy owing to complex treatment of diabetes and comorbidities. Polypharmacy is associated with increased risk of adverse reactions and decreased compliance. Therefore, the objectives of this study were to assess polypharmacy in people with...

Descripción completa

Detalles Bibliográficos
Autores principales: Thi Bui, Dieu Huyen, Nguyen, Bai Xuan, Truong, Dat Cong, Meyrowitsch, Dan Wolf, Søndergaard, Jens, Gammeltoft, Tine, Bygbjerg, Ib Christian, Jannie, Nielsen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8031303/
https://www.ncbi.nlm.nih.gov/pubmed/33831073
http://dx.doi.org/10.1371/journal.pone.0249849
_version_ 1783676144091922432
author Thi Bui, Dieu Huyen
Nguyen, Bai Xuan
Truong, Dat Cong
Meyrowitsch, Dan Wolf
Søndergaard, Jens
Gammeltoft, Tine
Bygbjerg, Ib Christian
Jannie, Nielsen
author_facet Thi Bui, Dieu Huyen
Nguyen, Bai Xuan
Truong, Dat Cong
Meyrowitsch, Dan Wolf
Søndergaard, Jens
Gammeltoft, Tine
Bygbjerg, Ib Christian
Jannie, Nielsen
author_sort Thi Bui, Dieu Huyen
collection PubMed
description OBJECTIVES: People with diabetes are at high risk of polypharmacy owing to complex treatment of diabetes and comorbidities. Polypharmacy is associated with increased risk of adverse reactions and decreased compliance. Therefore, the objectives of this study were to assess polypharmacy in people with type 2 diabetes (T2D) and associated diabetes-related factors in rural areas in Vietnam. METHOD: People with T2D (n = 806) who had received treatment for diabetes at a district hospital were invited to participate in a questionnaire-based cross-sectional survey. Polypharmacy was defined as ≥5 types of medicine and assessed as a) prescription medicine and non-prescription/over the counter (OTC) medicine and b) prescription medicine and non-prescription/OTC, herbal and traditional medicine, and dietary supplement. Multiple logistic regression was used to investigate the association between polypharmacy and diabetes specific factors: duration, comorbidities and diabetes-related distress. RESULTS: Of the people with T2D, 7.8% had a medicine use corresponding to polypharmacy (prescription medicine and non-prescription/OTC), and 40.8% when herbal and traditional medicine, and dietary supplement were included. Mean number of medicine intake (all types of medicines and supplements) were 3.8±1.5. The odd ratios (ORs) of polypharmacy (medicine and supplements) increased with diabetes duration (<1–5 years OR = 1.66; 95%CI: 1.09–2.53 and >5 years OR = 1.74; 95%CI: 1.14–2.64 as compared to ≤1-year duration of diabetes), number of comorbidities (1–2 comorbidities: OR = 2.0; 95%CI: 1.18–3.42; ≥3 comorbidities: OR = 2.63;95%CI: 1.50–4.61 as compared to no comorbidities), and suffering from diabetes-related distress (OR = 1.49; 95%CI: 1.11–2.01) as compared to those without distress. CONCLUSIONS: In rural northern Vietnam, persons with longer duration of T2D, higher number of comorbidities and diabetes-related stress have higher odds of having a medicine use corresponding to polypharmacy. A high proportion of people with T2D supplement their prescription, non-prescription/OTC medicine with herbal and traditional medicine and dietary supplements.
format Online
Article
Text
id pubmed-8031303
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-80313032021-04-14 Polypharmacy among people living with type 2 diabetes mellitus in rural communes in Vietnam Thi Bui, Dieu Huyen Nguyen, Bai Xuan Truong, Dat Cong Meyrowitsch, Dan Wolf Søndergaard, Jens Gammeltoft, Tine Bygbjerg, Ib Christian Jannie, Nielsen PLoS One Research Article OBJECTIVES: People with diabetes are at high risk of polypharmacy owing to complex treatment of diabetes and comorbidities. Polypharmacy is associated with increased risk of adverse reactions and decreased compliance. Therefore, the objectives of this study were to assess polypharmacy in people with type 2 diabetes (T2D) and associated diabetes-related factors in rural areas in Vietnam. METHOD: People with T2D (n = 806) who had received treatment for diabetes at a district hospital were invited to participate in a questionnaire-based cross-sectional survey. Polypharmacy was defined as ≥5 types of medicine and assessed as a) prescription medicine and non-prescription/over the counter (OTC) medicine and b) prescription medicine and non-prescription/OTC, herbal and traditional medicine, and dietary supplement. Multiple logistic regression was used to investigate the association between polypharmacy and diabetes specific factors: duration, comorbidities and diabetes-related distress. RESULTS: Of the people with T2D, 7.8% had a medicine use corresponding to polypharmacy (prescription medicine and non-prescription/OTC), and 40.8% when herbal and traditional medicine, and dietary supplement were included. Mean number of medicine intake (all types of medicines and supplements) were 3.8±1.5. The odd ratios (ORs) of polypharmacy (medicine and supplements) increased with diabetes duration (<1–5 years OR = 1.66; 95%CI: 1.09–2.53 and >5 years OR = 1.74; 95%CI: 1.14–2.64 as compared to ≤1-year duration of diabetes), number of comorbidities (1–2 comorbidities: OR = 2.0; 95%CI: 1.18–3.42; ≥3 comorbidities: OR = 2.63;95%CI: 1.50–4.61 as compared to no comorbidities), and suffering from diabetes-related distress (OR = 1.49; 95%CI: 1.11–2.01) as compared to those without distress. CONCLUSIONS: In rural northern Vietnam, persons with longer duration of T2D, higher number of comorbidities and diabetes-related stress have higher odds of having a medicine use corresponding to polypharmacy. A high proportion of people with T2D supplement their prescription, non-prescription/OTC medicine with herbal and traditional medicine and dietary supplements. Public Library of Science 2021-04-08 /pmc/articles/PMC8031303/ /pubmed/33831073 http://dx.doi.org/10.1371/journal.pone.0249849 Text en © 2021 Thi Bui et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Thi Bui, Dieu Huyen
Nguyen, Bai Xuan
Truong, Dat Cong
Meyrowitsch, Dan Wolf
Søndergaard, Jens
Gammeltoft, Tine
Bygbjerg, Ib Christian
Jannie, Nielsen
Polypharmacy among people living with type 2 diabetes mellitus in rural communes in Vietnam
title Polypharmacy among people living with type 2 diabetes mellitus in rural communes in Vietnam
title_full Polypharmacy among people living with type 2 diabetes mellitus in rural communes in Vietnam
title_fullStr Polypharmacy among people living with type 2 diabetes mellitus in rural communes in Vietnam
title_full_unstemmed Polypharmacy among people living with type 2 diabetes mellitus in rural communes in Vietnam
title_short Polypharmacy among people living with type 2 diabetes mellitus in rural communes in Vietnam
title_sort polypharmacy among people living with type 2 diabetes mellitus in rural communes in vietnam
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8031303/
https://www.ncbi.nlm.nih.gov/pubmed/33831073
http://dx.doi.org/10.1371/journal.pone.0249849
work_keys_str_mv AT thibuidieuhuyen polypharmacyamongpeoplelivingwithtype2diabetesmellitusinruralcommunesinvietnam
AT nguyenbaixuan polypharmacyamongpeoplelivingwithtype2diabetesmellitusinruralcommunesinvietnam
AT truongdatcong polypharmacyamongpeoplelivingwithtype2diabetesmellitusinruralcommunesinvietnam
AT meyrowitschdanwolf polypharmacyamongpeoplelivingwithtype2diabetesmellitusinruralcommunesinvietnam
AT søndergaardjens polypharmacyamongpeoplelivingwithtype2diabetesmellitusinruralcommunesinvietnam
AT gammeltofttine polypharmacyamongpeoplelivingwithtype2diabetesmellitusinruralcommunesinvietnam
AT bygbjergibchristian polypharmacyamongpeoplelivingwithtype2diabetesmellitusinruralcommunesinvietnam
AT jannienielsen polypharmacyamongpeoplelivingwithtype2diabetesmellitusinruralcommunesinvietnam