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Loop Dynamics and Enzyme Catalysis in Protein Tyrosine Phosphatases

[Image: see text] Protein tyrosine phosphatases (PTPs) play an important role in cellular signaling and have been implicated in human cancers, diabetes, and obesity. Despite shared catalytic mechanisms and transition states for the chemical steps of catalysis, catalytic rates within the PTP family v...

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Detalles Bibliográficos
Autores principales:	Crean, Rory M., Biler, Michal, van der Kamp, Marc W., Hengge, Alvan C., Kamerlin, Shina C. L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2021
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8031367/ https://www.ncbi.nlm.nih.gov/pubmed/33661624 http://dx.doi.org/10.1021/jacs.0c11806

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