Cargando…

PLD3 is a neuronal lysosomal phospholipase D associated with β-amyloid plaques and cognitive function in Alzheimer’s disease

Phospholipase D3 (PLD3) is a protein of unclear function that structurally resembles other members of the phospholipase D superfamily. A coding variant in this gene confers increased risk for the development of Alzheimer’s disease (AD), although the magnitude of this effect has been controversial. B...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nackenoff, Alex G., Hohman, Timothy J., Neuner, Sarah M., Akers, Carolyn S., Weitzel, Nicole C., Shostak, Alena, Ferguson, Shawn M., Mobley, Bret, Bennett, David A., Schneider, Julie A., Jefferson, Angela L., Kaczorowski, Catherine C., Schrag, Matthew S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8031396/ https://www.ncbi.nlm.nih.gov/pubmed/33830999 http://dx.doi.org/10.1371/journal.pgen.1009406

Ejemplares similares

Impaired JIP3-dependent axonal lysosome transport promotes amyloid plaque pathology
por: Gowrishankar, Swetha, et al.
Publicado: (2017)

Dopamine-Induced Plasticity, Phospholipase D (PLD) Activity and Cocaine-Cue Behavior Depend on PLD-Linked Metabotropic Glutamate Receptors in Amygdala
por: Krishnan, Balaji, et al.
Publicado: (2011)

Delivery of the Pseudomonas aeruginosa Phospholipase Effectors PldA and PldB in a VgrG- and H2-T6SS-Dependent Manner
por: Wettstadt, Sarah, et al.
Publicado: (2019)

PLD3 is accumulated on neuritic plaques in Alzheimer’s disease brains
por: Satoh, Jun-ichi, et al.
Publicado: (2014)

The Escherichia coli Phospholipase PldA Regulates Outer Membrane Homeostasis via Lipid Signaling
por: May, Kerrie L., et al.
Publicado: (2018)

Amygdala-Hippocampal Phospholipase D (PLD) Signaling As Novel Mechanism of Cocaine-Environment Maladaptive Conditioned Responses
por: Krishnan, Balaji
Publicado: (2016)

PHOSPHOLIPASE D (PLD) DRIVES CELL INVASION, TUMOR GROWTH AND METASTASIS IN A HUMAN BREAST CANCER XENOGRAPH MODEL
por: Henkels, Karen M., et al.
Publicado: (2013)

Erratum for May and Silhavy, “The Escherichia coli Phospholipase PldA Regulates Outer Membrane Homeostasis via Lipid Signaling”
por: May, Kerrie L., et al.
Publicado: (2018)

Quantification and characterization of the 5′ exonuclease activity of the lysosomal nuclease PLD3 by a novel cell-based assay
por: Cappel, Cedric, et al.
Publicado: (2020)

Method for organotypic tissue culture in the aged animal
por: Schommer, Jared, et al.
Publicado: (2017)

A Coxiella burnetii phospholipase A homolog pldA is required for optimal growth in macrophages and developmental form lipid remodeling
por: Stead, Christopher M., et al.
Publicado: (2018)

Proteomic Analysis of Arabidopsis pldα1 Mutants Revealed an Important Role of Phospholipase D Alpha 1 in Chloroplast Biogenesis
por: Takáč, Tomáš, et al.
Publicado: (2019)

Oxidative Stress Levels in the Brain Are Determined by Post-Mortem Interval and Ante-Mortem Vitamin C State but Not Alzheimer’s Disease Status
por: Eckman, Jared, et al.
Publicado: (2018)

PLD1 and PLD2 differentially regulate the balance of macrophage polarization in inflammation and tissue injury
por: Hwang, Won Chan, et al.
Publicado: (2020)

Cleavage of DNA and RNA by PLD3 and PLD4 limits autoinflammatory triggering by multiple sensors
por: Gavin, Amanda L., et al.
Publicado: (2021)

PLD3 and PLD4 are single stranded acid exonucleases that regulate endosomal nucleic acid sensing
por: Gavin, Amanda L., et al.
Publicado: (2018)

Genome-Wide Analysis of the Phospholipase D Family in Five Cotton Species, and Potential Role of GhPLD2 in Fiber Development and Anther Dehiscence
por: Ma, Changkai, et al.
Publicado: (2021)

Genome-wide in silico identification of phospholipase D (PLD) gene family from Corchorus capsularis and Corchorus olitorius: reveals their responses to plant stress
por: Sadat, Md. Abu, et al.
Publicado: (2022)

Digital devices and systems with PLD applications /
por: Miller, Michael A.
Publicado: (1997)

PLD4 Is Involved in Phagocytosis of Microglia: Expression and Localization Changes of PLD4 Are Correlated with Activation State of Microglia
por: Otani, Yoshinori, et al.
Publicado: (2011)

Collagenous Alzheimer amyloid plaque component impacts on the compaction of amyloid-β plaques
por: Hashimoto, Tadafumi, et al.
Publicado: (2020)

Structure and function of lysosomal phospholipase A2 and lecithin:cholesterol acyltransferase
por: Glukhova, Alisa, et al.
Publicado: (2015)

Inhibition of lysosomal phospholipase A2 predicts drug-induced phospholipidosis
por: Hinkovska-Galcheva, Vania, et al.
Publicado: (2021)

Adenoviral Gene Transfer of PLD1-D4 Enhances Insulin Sensitivity in Mice by Disrupting Phospholipase D1 Interaction with PED/PEA-15
por: Cassese, Angela, et al.
Publicado: (2013)

Upfront Taxane Could Be Superior to Pegylated Liposomal Doxorubicin (PLD): A Retrospective Real-World Analysis of Treatment Sequence Taxane–PLD versus PLD–Taxane in Patients with Metastatic Breast Cancer
por: Wallrabenstein, Till, et al.
Publicado: (2023)

Lysosomes relax in the cellular suburbs
por: Gowrishankar, Swetha, et al.
Publicado: (2016)

PLD3 Rare Variants Identified in Late-Onset Alzheimer’s Disease Affect Amyloid-β Levels in Cellular Model
por: Tan, Mengshan, et al.
Publicado: (2019)

Overexpression of Cucumber Phospholipase D alpha Gene (CsPLDα) in Tobacco Enhanced Salinity Stress Tolerance by Regulating Na(+)–K(+) Balance and Lipid Peroxidation
por: Ji, Tuo, et al.
Publicado: (2017)

MicroRNA miR-145-5p inhibits Phospholipase D 5 (PLD5) to downregulate cell proliferation and metastasis to mitigate prostate cancer
por: liu, Juanni, et al.
Publicado: (2021)

Corrigendum to: The transcription factors slug (SNAI2) and snail (SNAI1) regulate phospholipase D (PLD) promoter in opposite ways towards cancer cell invasion
Publicado: (2023)

Accumulation of amyloid-like Aβ(1–42) in AEL (autophagy–endosomal–lysosomal) vesicles: potential implications for plaque biogenesis
por: Ling, Daijun, et al.
Publicado: (2014)

Cinnamic acid activates PPARα to stimulate Lysosomal biogenesis and lower Amyloid plaque pathology in an Alzheimer’s disease mouse model
por: Chandra, Sujyoti, et al.
Publicado: (2018)

Novel allelic variation in the Phospholipase D alpha1 gene (OsPLDα1) of wild Oryza species implies to its low expression in rice bran
por: Kaur, Amandeep, et al.
Publicado: (2020)

Expression of Concern: Adenoviral Gene Transfer of PLD1-D4 Enhances Insulin Sensitivity in Mice by Disrupting Phospholipase D1 Interaction with PED/PEA-15
Publicado: (2022)

PLD gives nutritional advice to mTORC1
por: Short, Ben
Publicado: (2011)

PLD3 epigenetic changes in the hippocampus of Alzheimer’s disease
por: Blanco-Luquin, Idoia, et al.
Publicado: (2018)

Determinants of pH profile and acyl chain selectivity in lysosomal phospholipase A(2)
por: Hinkovska-Galcheva, Vania, et al.
Publicado: (2018)

Acid Sphingomyelinase, a Lysosomal and Secretory Phospholipase C, Is Key for Cellular Phospholipid Catabolism
por: Breiden, Bernadette, et al.
Publicado: (2021)

CsPLDα1 and CsPLDγ1 are differentially induced during leaf and fruit abscission and diurnally regulated in Citrus sinensis
por: Malladi, Anish, et al.
Publicado: (2008)

Lysosomal NEU1 deficiency affects Amyloid Precursor Protein levels and amyloid-β secretion via deregulated lysosomal exocytosis
por: Annunziata, Ida, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_trrobik4kgtnmkpgkkk83s1iqs