An iPSC line derived from a human acute myeloid leukemia cell line (HL-60-iPSC) retains leukemic abnormalities and displays myeloid differentiation defects

Cancer-derived iPSCs have provided valuable insight into oncogenesis, but human cancer cells can often be difficult to reprogram, especially in cases of complex genetic abnormalities. Here we report, to our knowledge, the first successful generation of an iPSC line from a human immortalized acute my...

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Detalles Bibliográficos
Autores principales: Yamasaki, Amanda E., Warshaw, Jane N., Kyalwazi, Beverly L., Matsui, Hiroko, Jepsen, Kristen, Panopoulos, Athanasia D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8031422/
https://www.ncbi.nlm.nih.gov/pubmed/33370871
http://dx.doi.org/10.1016/j.scr.2020.102096
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author Yamasaki, Amanda E.
Warshaw, Jane N.
Kyalwazi, Beverly L.
Matsui, Hiroko
Jepsen, Kristen
Panopoulos, Athanasia D.
author_facet Yamasaki, Amanda E.
Warshaw, Jane N.
Kyalwazi, Beverly L.
Matsui, Hiroko
Jepsen, Kristen
Panopoulos, Athanasia D.
author_sort Yamasaki, Amanda E.
collection PubMed
description Cancer-derived iPSCs have provided valuable insight into oncogenesis, but human cancer cells can often be difficult to reprogram, especially in cases of complex genetic abnormalities. Here we report, to our knowledge, the first successful generation of an iPSC line from a human immortalized acute myeloid leukemia (AML) cell line, the cell line HL-60. This iPSC line retains a majority of the leukemic genotype and displays defects in myeloid differentiation, thus providing a tool for modeling and studying AML.
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spelling pubmed-80314222021-04-08 An iPSC line derived from a human acute myeloid leukemia cell line (HL-60-iPSC) retains leukemic abnormalities and displays myeloid differentiation defects Yamasaki, Amanda E. Warshaw, Jane N. Kyalwazi, Beverly L. Matsui, Hiroko Jepsen, Kristen Panopoulos, Athanasia D. Stem Cell Res Article Cancer-derived iPSCs have provided valuable insight into oncogenesis, but human cancer cells can often be difficult to reprogram, especially in cases of complex genetic abnormalities. Here we report, to our knowledge, the first successful generation of an iPSC line from a human immortalized acute myeloid leukemia (AML) cell line, the cell line HL-60. This iPSC line retains a majority of the leukemic genotype and displays defects in myeloid differentiation, thus providing a tool for modeling and studying AML. 2020-11-23 2020-12 /pmc/articles/PMC8031422/ /pubmed/33370871 http://dx.doi.org/10.1016/j.scr.2020.102096 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ).
spellingShingle Article
Yamasaki, Amanda E.
Warshaw, Jane N.
Kyalwazi, Beverly L.
Matsui, Hiroko
Jepsen, Kristen
Panopoulos, Athanasia D.
An iPSC line derived from a human acute myeloid leukemia cell line (HL-60-iPSC) retains leukemic abnormalities and displays myeloid differentiation defects
title An iPSC line derived from a human acute myeloid leukemia cell line (HL-60-iPSC) retains leukemic abnormalities and displays myeloid differentiation defects
title_full An iPSC line derived from a human acute myeloid leukemia cell line (HL-60-iPSC) retains leukemic abnormalities and displays myeloid differentiation defects
title_fullStr An iPSC line derived from a human acute myeloid leukemia cell line (HL-60-iPSC) retains leukemic abnormalities and displays myeloid differentiation defects
title_full_unstemmed An iPSC line derived from a human acute myeloid leukemia cell line (HL-60-iPSC) retains leukemic abnormalities and displays myeloid differentiation defects
title_short An iPSC line derived from a human acute myeloid leukemia cell line (HL-60-iPSC) retains leukemic abnormalities and displays myeloid differentiation defects
title_sort ipsc line derived from a human acute myeloid leukemia cell line (hl-60-ipsc) retains leukemic abnormalities and displays myeloid differentiation defects
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8031422/
https://www.ncbi.nlm.nih.gov/pubmed/33370871
http://dx.doi.org/10.1016/j.scr.2020.102096
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